粘着斑复合体为细菌滑行运动提供动力的证据。
Evidence that focal adhesion complexes power bacterial gliding motility.
作者信息
Mignot Tâm, Shaevitz Joshua W, Hartzell Patricia L, Zusman David R
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Science. 2007 Feb 9;315(5813):853-6. doi: 10.1126/science.1137223.
Abstract
The bacterium Myxococcus xanthus has two motility systems: S motility, which is powered by type IV pilus retraction, and A motility, which is powered by unknown mechanism(s). We found that A motility involved transient adhesion complexes that remained at fixed positions relative to the substratum as cells moved forward. Complexes assembled at leading cell poles and dispersed at the rear of the cells. When cells reversed direction, the A-motility clusters relocalized to the new leading poles together with S-motility proteins. The Frz chemosensory system coordinated the two motility systems. The dynamics of protein cluster localization suggest that intracellular motors and force transmission by dynamic focal adhesions can power bacterial motility.
摘要
黄色粘球菌有两种运动系统
S运动系统，由IV型菌毛收缩提供动力；A运动系统，其动力来源机制不明。我们发现A运动系统涉及瞬时粘附复合体，当细胞向前移动时，这些复合体相对于基质保持在固定位置。复合体在细胞前端极组装，并在细胞后端分散。当细胞改变方向时，A运动簇与S运动蛋白一起重新定位到新的前端极。Frz化学感应系统协调这两种运动系统。蛋白质簇定位的动态变化表明，细胞内马达和动态粘着斑的力传递可为细菌运动提供动力。
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