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本文引用的文献

1
Regulation of apicomplexan actin-based motility.顶复门寄生虫基于肌动蛋白的运动调控。
Nat Rev Microbiol. 2006 Aug;4(8):621-8. doi: 10.1038/nrmicro1465.
2
Regulated pole-to-pole oscillations of a bacterial gliding motility protein.一种细菌滑行运动蛋白的规则性极对极振荡。
Science. 2005 Nov 4;310(5749):855-7. doi: 10.1126/science.1119052.
3
Force and flexibility of flailing myxobacteria.游动黏细菌的力量与灵活性。
Biophys J. 2005 Aug;89(2):945-50. doi: 10.1529/biophysj.105.062513. Epub 2005 May 20.
4
Bacillus subtilis actin-like protein MreB influences the positioning of the replication machinery and requires membrane proteins MreC/D and other actin-like proteins for proper localization.枯草芽孢杆菌肌动蛋白样蛋白MreB影响复制机器的定位，并且需要膜蛋白MreC/D和其他肌动蛋白样蛋白来实现正确定位。
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5
AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus.AglZ是一种丝状形成的卷曲螺旋蛋白，是黄色粘球菌冒险性滑行运动所必需的。
J Bacteriol. 2004 Sep;186(18):6168-78. doi: 10.1128/JB.186.18.6168-6178.2004.
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Focal adhesion regulation of cell behavior.细胞行为的粘着斑调节
Biochim Biophys Acta. 2004 Jul 5;1692(2-3):103-19. doi: 10.1016/j.bbamcr.2004.04.007.
7
Dysfunctional MreB inhibits chromosome segregation in Escherichia coli.功能失调的MreB抑制大肠杆菌中的染色体分离。
EMBO J. 2003 Oct 1;22(19):5283-92. doi: 10.1093/emboj/cdg504.
8
Extracellular polysaccharides mediate pilus retraction during social motility of Myxococcus xanthus.胞外多糖在黄色黏球菌群体运动过程中介导菌毛回缩。
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5443-8. doi: 10.1073/pnas.0836639100. Epub 2003 Apr 18.
9
How myxobacteria glide.粘细菌如何滑行。
Curr Biol. 2002 Mar 5;12(5):369-77. doi: 10.1016/s0960-9822(02)00716-9.
10
Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus.细胞丝状化对黄色黏球菌冒险性和社会性滑行运动的影响。
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15178-83. doi: 10.1073/pnas.96.26.15178.

粘着斑复合体为细菌滑行运动提供动力的证据。

Evidence that focal adhesion complexes power bacterial gliding motility.

作者信息

Mignot Tâm, Shaevitz Joshua W, Hartzell Patricia L, Zusman David R

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

出版信息

Science. 2007 Feb 9;315(5813):853-6. doi: 10.1126/science.1137223.

DOI:10.1126/science.1137223
PMID:17289998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4095873/
Abstract

The bacterium Myxococcus xanthus has two motility systems: S motility, which is powered by type IV pilus retraction, and A motility, which is powered by unknown mechanism(s). We found that A motility involved transient adhesion complexes that remained at fixed positions relative to the substratum as cells moved forward. Complexes assembled at leading cell poles and dispersed at the rear of the cells. When cells reversed direction, the A-motility clusters relocalized to the new leading poles together with S-motility proteins. The Frz chemosensory system coordinated the two motility systems. The dynamics of protein cluster localization suggest that intracellular motors and force transmission by dynamic focal adhesions can power bacterial motility.

摘要

黄色粘球菌有两种运动系统

S运动系统，由IV型菌毛收缩提供动力；A运动系统，其动力来源机制不明。我们发现A运动系统涉及瞬时粘附复合体，当细胞向前移动时，这些复合体相对于基质保持在固定位置。复合体在细胞前端极组装，并在细胞后端分散。当细胞改变方向时，A运动簇与S运动蛋白一起重新定位到新的前端极。Frz化学感应系统协调这两种运动系统。蛋白质簇定位的动态变化表明，细胞内马达和动态粘着斑的力传递可为细菌运动提供动力。