慢性心力衰竭患者运动诱导的脂质过氧化增加：与运动不耐受的关系。
Exercise-induced increase in lipid peroxidation in patients with chronic heart failure: relation to exercise intolerance.
作者信息
Sayar Nurten, Terzi Sait, Yilmaz Hale Yaka, Tangurek Burak, Bilsel Tuba, Cakmak Nazmiye, Orhan Lutfullah, Emre Ayse, Ciloglu Figen, Peker Ismail, Yesilcimen Kemal
机构信息
Department of Cardiology, Siyami Ersek Cardiovascular Research and Training Hospital, Istanbul, Turkey.
出版信息
Cardiology. 2007;108(4):307-13. doi: 10.1159/000099100. Epub 2007 Feb 9.
BACKGROUND
Little is known about the relationship between exercise intolerance and lipid peroxidation in chronic heart failure (CHF) patients. This study was designed to investigate the relationship between exercise-induced plasma malondialdehyde (MDA) changes in CHF patients and to determine whether there is any association between plasma MDA levels and exercise capacity assessed by cardiopulmonary exercise testing.
METHODS
Cardiopulmonary exercise testing was applied to 31 CHF patients (16 ischemic, 15 idiopathic) and controls. Rest and peak exercise blood samples were analyzed for MDA.
RESULTS
Patients with CHF had elevation of plasma MDA levels during exercise compared with controls (p < 0.001 vs. p = 0.588). MDA change remained significant both in ischemic and idiopathic cardiomyopathy groups (p < 0.05 and p < 0.01, respectively). Delta MDA (peak exercise MDA - rest MDA) showed significant inverse correlation with peak oxygen consumption in patients with CHF.
CONCLUSION
Lipid peroxidation is increased in patients with CHF during exercise regardless of etiology, and this increase is inversely related to oxygen consumption.
背景
关于慢性心力衰竭（CHF）患者运动不耐受与脂质过氧化之间的关系，目前所知甚少。本研究旨在调查CHF患者运动诱导的血浆丙二醛（MDA）变化之间的关系，并确定血浆MDA水平与通过心肺运动试验评估的运动能力之间是否存在关联。
方法
对31例CHF患者（16例缺血性，15例特发性）和对照组进行心肺运动试验。分析静息和运动峰值时的血样中的MDA。
结果
与对照组相比，CHF患者运动期间血浆MDA水平升高（p < 0.001 vs. p = 0.588）。在缺血性和特发性心肌病组中，MDA变化均保持显著（分别为p < 0.05和p < 0.01）。CHF患者中，ΔMDA（运动峰值MDA - 静息MDA）与峰值耗氧量呈显著负相关。
结论
无论病因如何，CHF患者运动期间脂质过氧化均增加，且这种增加与耗氧量呈负相关。
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