[Effect of 17beta-estradiol on content of cyclic nucleotides and protein kinases A and C activity in human adrenal cortex].

The influence of 17beta-estradiol on cAMP and cGMP levels, protein kinases A and C activityand corticosteroids secretion was investigated in postoperative human adrenal cortex tissue. cAMP accumulation in adrenocorticocytes increased uiider the influence of 17beta-estradiol. In vitro estradiol raised the activities of protein kinases A and C in membrane fraction of adrenal cortex tissue. Significant increasing of steroidogenesis was observed. These data support our conclusion that cAMP dependent siganling system is involved in activation of steroidogenesis by 17beta-estradiol.