Mironova V I, Rybnikova E A
Ross Fiziol Zh Im I M Sechenova. 2006 Sep;92(9):1111-21.
Possible role of extrahypothalamic corticotrophin-releasing hormone (CRH) and vasopressin-producing centers in post-stress depression development were studied. We used genetically selected strains: KHA (Koltushi High Avoidance) and KLA (Koltushi Low Avoidance) rats developing different types of depression in the "learned helplessness" paradigm: the model analogues of endogenous (KHA strain) and exogenous (KLA strain) depression. Interstrain differences of control and stress-induced CRH- and vasopressin-expression in hippocampus and neocortex in the course of depression development in KHA and KLA rats were revealed using immuno-histochemical studies. It has been shown that a significant increase of CRH- and vasopressin-immune reactivity in hippocampus and neocortex of KHA rats occurred on the 10th post-stress day. We detected also decreased CRH- and vasopressin-expression in dorsal hippocampus, and increased CRH-immune reactivity in neocortex of KLA rats in the same post-stress period. These findings imply that extrahypothalamic CRH- and vasopressin-ergic systems appear to be involved in pathogenesis mechanisms of model analogues of endogenous and exogenous depression in different ways.
研究了下丘脑外促肾上腺皮质激素释放激素（CRH）和产生加压素的中枢在应激后抑郁症发生中的可能作用。我们使用了基因选择的品系：KHA（科尔图希高回避型）和KLA（科尔图希低回避型）大鼠，它们在“习得性无助”范式中会发展出不同类型的抑郁症，即内源性（KHA品系）和外源性（KLA品系）抑郁症的模型类似物。通过免疫组织化学研究揭示了KHA和KLA大鼠在抑郁症发展过程中，海马体和新皮质中对照和应激诱导的CRH和加压素表达的品系间差异。结果表明，在应激后第10天，KHA大鼠海马体和新皮质中CRH和加压素免疫反应性显著增加。我们还检测到，在相同的应激后时期，KLA大鼠背侧海马体中CRH和加压素表达降低，新皮质中CRH免疫反应性增加。这些发现表明，下丘脑外CRH和加压素能系统似乎以不同方式参与内源性和外源性抑郁症模型类似物的发病机制。
