Velthuis A G J, Bouma A, Katsma W E A, Nodelijk G, De Jong M C M
Business Economics, Wageningen University, Wageningen, The Netherlands.
Epidemiol Infect. 2007 Feb;135(2):202-17. doi: 10.1017/S095026880600673X.
Interactions between pathogens and hosts at the population level should be considered when studying the effectiveness of control measures for infectious diseases. The advantage of doing transmission experiments compared to field studies is that they offer a controlled environment in which the effect of a single factor can be investigated, while variation due to other factors is minimized. This paper gives an overview of the biological and mathematical aspects, bottlenecks and solutions of developing and executing transmission experiments with animals. Different methods of analysis and different experimental designs are discussed. Final size methods are often used for analysing transmission data, but have never been published in a refereed journal; therefore, they will be described in detail in this paper. We hope that this information is helpful for scientists who are considering performing transmission experiments.
在研究传染病控制措施的有效性时，应考虑病原体与宿主在种群水平上的相互作用。与实地研究相比，进行传播实验的优势在于，它们提供了一个可控的环境，在这个环境中可以研究单一因素的影响，同时将其他因素引起的变异降至最低。本文概述了开展和实施动物传播实验的生物学和数学方面、瓶颈问题及解决方案。讨论了不同的分析方法和不同的实验设计。最终规模法常用于分析传播数据，但从未在同行评审期刊上发表过；因此，本文将对其进行详细描述。我们希望这些信息对正在考虑进行传播实验的科学家有所帮助。
