小型动物传播实验的设计与分析
Design and analysis of small-scale transmission experiments with animals.
作者信息
Velthuis A G J, Bouma A, Katsma W E A, Nodelijk G, De Jong M C M
机构信息
Business Economics, Wageningen University, Wageningen, The Netherlands.
出版信息
Epidemiol Infect. 2007 Feb;135(2):202-17. doi: 10.1017/S095026880600673X.
Abstract
Interactions between pathogens and hosts at the population level should be considered when studying the effectiveness of control measures for infectious diseases. The advantage of doing transmission experiments compared to field studies is that they offer a controlled environment in which the effect of a single factor can be investigated, while variation due to other factors is minimized. This paper gives an overview of the biological and mathematical aspects, bottlenecks and solutions of developing and executing transmission experiments with animals. Different methods of analysis and different experimental designs are discussed. Final size methods are often used for analysing transmission data, but have never been published in a refereed journal; therefore, they will be described in detail in this paper. We hope that this information is helpful for scientists who are considering performing transmission experiments.
摘要
在研究传染病控制措施的有效性时，应考虑病原体与宿主在种群水平上的相互作用。与实地研究相比，进行传播实验的优势在于，它们提供了一个可控的环境，在这个环境中可以研究单一因素的影响，同时将其他因素引起的变异降至最低。本文概述了开展和实施动物传播实验的生物学和数学方面、瓶颈问题及解决方案。讨论了不同的分析方法和不同的实验设计。最终规模法常用于分析传播数据，但从未在同行评审期刊上发表过；因此，本文将对其进行详细描述。我们希望这些信息对正在考虑进行传播实验的科学家有所帮助。
相似文献
1
Design and analysis of small-scale transmission experiments with animals.小型动物传播实验的设计与分析
Epidemiol Infect. 2007 Feb;135(2):202-17. doi: 10.1017/S095026880600673X.
2
Call for human factors to be considered in animal disease outbreaks.呼吁在动物疾病爆发中考虑人为因素。
Vet Rec. 2012 Jun 2;170(22):554. doi: 10.1136/vr.e3588.
3
Climate change: effects on animal disease systems and implications for surveillance and control.气候变化：对动物疾病系统的影响及其对监测与防控的意义
Rev Sci Tech. 2008 Aug;27(2):339-54.
4
Epidemiological effects of group size variation in social species.社会物种中群体大小变化的流行病学影响。
J R Soc Interface. 2013 Apr 10;10(83):20130206. doi: 10.1098/rsif.2013.0206. Print 2013 Jun 6.
5
Species coexistence and pathogens with frequency-dependent transmission.物种共存与具有频率依赖性传播的病原体。
Am Nat. 2005 Jul;166(1):112-8. doi: 10.1086/430674. Epub 2005 Apr 21.
6
Network frailty and the geometry of herd immunity.网络脆弱性与群体免疫的几何学
Proc Biol Sci. 2006 Nov 7;273(1602):2743-8. doi: 10.1098/rspb.2006.3636.
7
Implementing revised guidelines on euthanasia and preventing farm animal disease transmission.实施关于安乐死的修订准则并预防农场动物疾病传播。
Lab Anim (NY). 2001 Jun;30(6):16.
8
The origin of human pathogens: evaluating the role of agriculture and domestic animals in the evolution of human disease.人类病原体的起源：评估农业和家畜在人类疾病演变中的作用。
Biol Rev Camb Philos Soc. 2006 Aug;81(3):369-82. doi: 10.1017/S1464793106007020. Epub 2006 May 4.
9
The walrus and the carpenter were walking close at hand.
Acta Vet Scand Suppl. 2003;100:45-7.
10
Zoonoses and public health. Zoonoses associated with our animal companions. Guest editorial.人畜共患病与公共卫生。与我们的动物伙伴相关的人畜共患病。特邀社论。
Zoonoses Public Health. 2008 Oct;55(8-10):377. doi: 10.1111/j.1863-2378.2008.01180.x.
引用本文的文献
1
Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.实验感染模型及其在虾类白斑综合征病毒（WSSV）研究中的应用。
Viruses. 2024 May 20;16(5):813. doi: 10.3390/v16050813.
2
Combining a parsimonious mathematical model with infection data from tailor-made experiments to understand environmental transmission.结合简约的数学模型和定制实验中的感染数据来理解环境传播。
Sci Rep. 2023 Aug 10;13(1):12986. doi: 10.1038/s41598-023-38817-z.
3
Efficacy of a recombinant turkey herpesvirus (H9) vaccine against H9N2 avian influenza virus in chickens with maternal-derived antibodies.重组火鸡疱疹病毒（H9）疫苗对具有母源抗体的鸡群中H9N2禽流感病毒的效力。
Front Microbiol. 2023 Jan 26;13:1107975. doi: 10.3389/fmicb.2022.1107975. eCollection 2022.
4
Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.用于估计传染病传播遗传和非遗传影响的最佳实验设计。
Genet Sel Evol. 2022 Sep 5;54(1):59. doi: 10.1186/s12711-022-00747-1.
5
Exact Bayesian inference of epidemiological parameters from mortality data: application to African swine fever virus.基于死亡率数据的流行病学参数精确贝叶斯推断：应用于非洲猪瘟病毒
J R Soc Interface. 2022 Mar;19(188):20220013. doi: 10.1098/rsif.2022.0013. Epub 2022 Mar 9.
6
The SARS-CoV-2 Reproduction Number R in Cats.猫体内 SARS-CoV-2 的繁殖数 R。
Viruses. 2021 Dec 10;13(12):2480. doi: 10.3390/v13122480.
7
Revealing mechanisms of infectious disease spread through empirical contact networks.通过经验性接触网络揭示传染病传播的机制。
PLoS Comput Biol. 2021 Dec 20;17(12):e1009604. doi: 10.1371/journal.pcbi.1009604. eCollection 2021 Dec.
8
Vaccination with inactivated virus against low pathogenic avian influenza subtype H9N2 does not prevent virus transmission in chickens.用灭活病毒对低致病性禽流感H9N2亚型进行疫苗接种不能防止病毒在鸡群中传播。
J Virus Erad. 2021 Sep 22;7(3):100055. doi: 10.1016/j.jve.2021.100055. eCollection 2021 Sep.
9
Microbial dysbiosis reflects disease resistance in diverse coral species.微生物失调反映了不同珊瑚物种的疾病抵抗力。
Commun Biol. 2021 Jun 3;4(1):679. doi: 10.1038/s42003-021-02163-5.
10
SARS-CoV-2 infection in cats and dogs in infected mink farms.感染新冠病毒的貂场中的猫和狗感染了 SARS-CoV-2。
Transbound Emerg Dis. 2022 Sep;69(5):3001-3007. doi: 10.1111/tbed.14173. Epub 2021 Jun 10.
本文引用的文献
1
Contributions to the mathematical theory of epidemics: V. Analysis of experimental epidemics of mouse-typhoid; a bacterial disease conferring incomplete immunity.对流行病数学理论的贡献：V. 小鼠伤寒实验性流行病分析；一种产生不完全免疫的细菌性疾病。
J Hyg (Lond). 1939 May;39(3):271-88. doi: 10.1017/s0022172400011918.
2
Contributions to the mathematical theory of epidemics: IV. Analysis of experimental epidemics of the virus disease mouse ectromelia.对流行病数学理论的贡献：IV. 病毒病小鼠脱脚病实验性流行病分析
J Hyg (Lond). 1937 Apr;37(2):172-87. doi: 10.1017/s0022172400034902.
3
Design and analysis of an Actinobacillus pleuropneumoniae transmission experiment.猪胸膜肺炎放线杆菌传播实验的设计与分析
Prev Vet Med. 2003 Jul 30;60(1):53-68. doi: 10.1016/s0167-5877(03)00082-5.
4
Transmission of Actinobacillus pleuropneumoniae in pigs is characterized by variation in infectivity.猪胸膜肺炎放线杆菌在猪群中的传播具有感染性变异的特点。
Epidemiol Infect. 2002 Aug;129(1):203-14. doi: 10.1017/s0950268802007252.
5
Within- and between-pen transmission of Classical Swine Fever Virus: a new method to estimate the basic reproduction ratio from transmission experiments.经典猪瘟病毒在栏内和栏间的传播：一种从传播实验估计基本繁殖数的新方法。
Epidemiol Infect. 2002 Apr;128(2):293-9. doi: 10.1017/s0950268801006537.
6
Quantification of transmission in one-to-one experiments.一对一实验中传播的量化。
Epidemiol Infect. 2002 Apr;128(2):193-204. doi: 10.1017/s0950268801006707.
7
Classical swine fever (CSF) marker vaccine. Trial III. Evaluation of discriminatory ELISAs.经典猪瘟（CSF）标记疫苗。试验III。鉴别ELISA的评估。
Vet Microbiol. 2001 Nov 8;83(2):121-36. doi: 10.1016/s0378-1135(01)00411-4.
8
Pseudorabies virus is transmitted among vaccinated conventional pigs, but not among vaccinated SPF pigs.
Vet Microbiol. 2001 Jun 22;80(4):303-12. doi: 10.1016/s0378-1135(01)00318-2.
9
The influence of maternal immunity on the transmission of pseudorabies virus and on the effectiveness of vaccination.母体免疫对伪狂犬病病毒传播及疫苗接种效果的影响。
Vaccine. 1997 Feb;15(3):287-94. doi: 10.1016/s0264-410x(96)00179-x.
Zotero 插件