猪胸膜肺炎放线杆菌在猪群中的传播具有感染性变异的特点。
Transmission of Actinobacillus pleuropneumoniae in pigs is characterized by variation in infectivity.
作者信息
Velthuis A G J, DE Jong M C M, Stockhofe N, Vermeulen T M M, Kamp E M
机构信息
Quantitative Veterinary Epidemiology, Institute for Animal Science and Health, Edelhertweg, Lelystad, The Netherlands.
出版信息
Epidemiol Infect. 2002 Aug;129(1):203-14. doi: 10.1017/s0950268802007252.
Ten transmission trials with Actinobacillus pleuropneumoniae were carried out. The observed transmission was highly variable, which was surprising since the design of the trials was very similar. We investigated whether the variable transmission could be explained by variation in infectivity of A. pleuropneumoniae infected pigs. We looked for measurable characteristics, which could be indicative for infectious pigs or for the level of infectivity. The characteristic that appeared to be most indicative for a pig being infectious was an A. pleuropneumoniae positive tonsil at necropsy. The characteristic that was correlated to the level of infectivity was the number of A. pleuropneumoniae colonies isolated from the nasal swab, i.e. the probability for an infectious pig to infect a susceptible pig was tenfold higher on days where at least ten colonies were isolated. In this study it is shown that it is possible to measure the bacterial transmission of A. pleuropneumoniae under controlled circumstances if variation in infectivity is taken into account.
进行了十次胸膜肺炎放线杆菌的传播试验。观察到的传播情况差异很大，这令人惊讶，因为试验设计非常相似。我们研究了这种可变传播是否可以用感染胸膜肺炎放线杆菌的猪的感染性变化来解释。我们寻找了可测量的特征，这些特征可以表明感染猪或感染水平。尸检时胸膜肺炎放线杆菌阳性扁桃体似乎是猪具有传染性的最具指示性的特征。与感染水平相关的特征是从鼻拭子中分离出的胸膜肺炎放线杆菌菌落数量，即，在分离出至少十个菌落的日子里，感染猪感染易感猪的概率要高十倍。本研究表明，如果考虑到感染性的变化，在可控条件下测量胸膜肺炎放线杆菌的细菌传播是可能的。
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