大鼠慢性重复经颅磁刺激抗抑郁样作用的性别差异
Sex differences in antidepressant-like effect of chronic repetitive transcranial magnetic stimulation in rats.
作者信息
Yang Yuye, Li Wei, Zhu Bin, Liu Yanyou, Yang Bo, Wang Hongxing, Wang Zhengrong
机构信息
Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, People's Republic of China.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):735-40. doi: 10.1016/j.pnpbp.2007.01.007. Epub 2007 Jan 16.
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurophysiological technique. Pre-clinical and clinical studies supported that rTMS might have antidepressant effects. However, whether antidepressant effect of chronic rTMS is gender-dependent is still unknown. In this study, male and female Wistar rats received 10-day rTMS (4 trains of 15 Hz; 200 stimuli/day; 1.0 T) or control condition, and then were subjected to the forced-swim test (FST). We found that female rats consistently showed higher activity levels than males in FST and revealed the significant effects of gender and rTMS as well as the interaction of gender and rTMS. The result suggested the antidepressant-like effects of chronic rTMS on behavioral components in FST are gender-dependent. The gender discrepancy related to rTMS should not be neglected in antidepressant treatment of rTMS.
重复经颅磁刺激（rTMS）是一种非侵入性神经生理学技术。临床前和临床研究支持rTMS可能具有抗抑郁作用。然而，慢性rTMS的抗抑郁作用是否存在性别差异仍不清楚。在本研究中，雄性和雌性Wistar大鼠接受为期10天的rTMS（4组，15Hz；每天200次刺激；1.0T）或对照处理，然后进行强迫游泳试验（FST）。我们发现，在FST中，雌性大鼠的活动水平始终高于雄性大鼠，并揭示了性别、rTMS的显著影响以及性别与rTMS的相互作用。结果表明，慢性rTMS对FST行为成分的抗抑郁样作用存在性别差异。在rTMS的抗抑郁治疗中，不应忽视与rTMS相关的性别差异。
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