Tsutsumi Takashi, Fujiki Minoru, Akiyoshi Jotaro, Horinouchi Yukiko, Isogawa Koichi, Hori Shigeaki, Nagayama Haruo
Department of Neuropsychiatry, Oita Medical University, Hasama-Machi, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan;26(1):107-11. doi: 10.1016/s0278-5846(01)00227-5.
Repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive shock (ECS) have been shown to affect mood in health and disease. Evidence to date has demonstrated an antidepressant potential for rTMS and electroconvulsive therapy (ECT). The present experiment, aimed at comparing the effects of ECS and rTMS in rats, employed one test used for screening of antidepressant activity: the forced swimming test (FST). In this study, the authors investigated whether chronic rTMS influenced active behavior in the rat FST, similar to ECS. Male Wistar rats received rTMS treatment daily, for 10 days as is commonly used for ECT treatment. Control rats received sham treatment by placing the stimulation coil in a perpendicular position to the rat's head. Passing a current through earclip electrodes for 1 s induced ECS. The control animals were treated identically, but current was not applied. The FST was carried out 24 h after the last rTMS or ECS. The immobility time in the FST was not significantly affected by rTMS and ECS for 1 day. The immobility time in the FST was significantly shortened at rTMS and ECS for 10 days. Chronic treatment with rTMS, similar to chronic treatment with ECS, decreased the immobility time in the FST. These results indicate that chronic treatment with rTMS might have antidepressant effect similar to chronic treatment with ECS.
重复经颅磁刺激（rTMS）和电惊厥休克（ECS）已被证明会影响健康和疾病状态下的情绪。迄今为止的证据表明rTMS和电惊厥治疗（ECT）具有抗抑郁潜力。本实验旨在比较ECS和rTMS对大鼠的影响，采用了一种用于筛选抗抑郁活性的测试：强迫游泳试验（FST）。在本研究中，作者调查了慢性rTMS是否会像ECS一样影响大鼠FST中的主动行为。雄性Wistar大鼠每天接受rTMS治疗，持续10天，这是ECT治疗常用的时间。对照大鼠通过将刺激线圈垂直于大鼠头部放置接受假治疗。通过耳夹电极通以电流1 s诱导ECS。对照动物接受相同处理，但不施加电流。在最后一次rTMS或ECS治疗24小时后进行FST。rTMS和ECS在1天时对FST中的不动时间没有显著影响。rTMS和ECS在10天时显著缩短了FST中的不动时间。与ECS慢性治疗类似，rTMS慢性治疗减少了FST中的不动时间。这些结果表明，rTMS慢性治疗可能具有与ECS慢性治疗相似的抗抑郁作用。
