Fergusson David M, Horwood L John, Ridder Elizabeth M
Christchurch Health & Development Study, Christchurch School of Medicine & Health Sciences, P.O. Box 4345, Christchurch, New Zealand.
Drug Alcohol Depend. 2007 Apr;88 Suppl 1:S14-26. doi: 10.1016/j.drugalcdep.2006.12.011. Epub 2007 Feb 9.
This paper examines the linkages between conduct problems and attentional problems in middle childhood and adolescence and later substance use, abuse and dependence in young adulthood.
Data were gathered over the course of a 25-year longitudinal study of a birth cohort of 1265 New Zealand born children. These data included: (a) measures of conduct and attentional problems in middle childhood (7-9 years) and adolescence (14-16 years); (b) measures of substance use, abuse and dependence from 18-25 years; and (c) confounding social, family and related factors.
Statistical modelling produced a consistent set of results showing: (i) conduct problems in childhood and adolescence were generally related to later substance use, abuse and dependence even after control for attentional problems and confounders; (ii) attentional problems were largely unrelated to later substance use, abuse and dependence after control for conduct problems and confounders.
Conduct problems in both middle childhood and adolescence are related to increased risks of longer-term substance use, abuse and dependence. Any association between early attentional problems and later substance use abuse and dependence is largely mediated via the association between conduct and attentional problems.
本文探讨童年中期和青少年期的行为问题与注意力问题之间的联系，以及其与青年期后期物质使用、滥用和依赖之间的关联。
数据来自一项对1265名新西兰出生儿童的出生队列进行的为期25年的纵向研究。这些数据包括：（a）童年中期（7 - 9岁）和青少年期（14 - 16岁）的行为和注意力问题测量；（b）18 - 25岁的物质使用、滥用和依赖测量；以及（c）混杂的社会、家庭和相关因素。
统计建模得出了一组一致的结果，表明：（i）即使在控制了注意力问题和混杂因素之后，童年期和青少年期的行为问题通常仍与后期的物质使用、滥用和依赖有关；（ii）在控制了行为问题和混杂因素之后，注意力问题在很大程度上与后期的物质使用、滥用和依赖无关。
童年中期和青少年期的行为问题都与长期物质使用、滥用和依赖风险增加有关。早期注意力问题与后期物质使用、滥用和依赖之间的任何关联在很大程度上是通过行为问题与注意力问题之间的关联来介导的。
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