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大麻使用与成人多动症症状。

Cannabis use and adult ADHD symptoms.

作者信息

Fergusson David M, Boden Joseph M

机构信息

University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.

出版信息

Drug Alcohol Depend. 2008 May 1;95(1-2):90-6. doi: 10.1016/j.drugalcdep.2007.12.012. Epub 2008 Feb 1.

Abstract

BACKGROUND

The present study examined the associations between cannabis use in adolescence and young adulthood and self-reported adult attention deficit/hyperactivity disorder (ADHD) symptoms in adulthood.

METHODS

A 25-year prospective longitudinal study of the health, development, and adjustment of a birth cohort of 1265 New Zealand children. Measures included assessments of adolescent and young adult cannabis use and ADHD symptoms at age 25, measures of childhood socioeconomic disadvantage, family adversity, childhood and early adolescent behavioural adjustment and cognitive ability, and adolescent and young adult other drug use.

RESULTS

Cannabis use by age 25 was significantly (p<.0001) associated with increasing self-reported adult ADHD symptoms at age 25. Adjustment of the association for potentially confounding factors from childhood and early adolescence reduced the magnitude of the association, but it remained statistically significant (p<.0001). However, control for the mediating effects of other drug use in adolescence and early adulthood reduced the association between cannabis use and adult ADHD symptoms to statistical non-significance (p>.20).

CONCLUSIONS

The current study suggested that the association between cannabis use and adult ADHD symptoms was mediated by other substance use that was associated with cannabis use. The results suggest that cannabis use leads to other drug use, which in turn leads to increased ADHD symptoms. However, it should be noted that the potential influence of such factors as genetic predispositions may still be unaccounted for.

摘要

背景

本研究调查了青少年期和青年期使用大麻与成年后自我报告的注意力缺陷多动障碍(ADHD)症状之间的关联。

方法

对1265名新西兰儿童出生队列的健康、发育和适应情况进行了为期25年的前瞻性纵向研究。测量指标包括对青少年期和青年期使用大麻情况以及25岁时ADHD症状的评估、儿童期社会经济劣势、家庭逆境、儿童期和青少年早期行为调整及认知能力的测量,以及青少年期和青年期使用其他药物的情况。

结果

25岁时使用大麻与25岁时自我报告的成年ADHD症状增加显著相关(p<.0001)。对来自儿童期和青少年早期的潜在混杂因素进行关联调整后,关联强度有所降低,但仍具有统计学意义(p<.0001)。然而,控制青少年期和青年期使用其他药物的中介效应后,大麻使用与成年ADHD症状之间的关联降至统计学无显著性(p>.20)。

结论

当前研究表明,大麻使用与成年ADHD症状之间的关联是由与大麻使用相关的其他物质使用介导的。结果表明,大麻使用导致其他药物使用,进而导致ADHD症状增加。然而,应该注意的是,遗传易感性等因素的潜在影响可能仍未得到解释。

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