D'Eredita' Giovanni, Giardina Carmela, Ingravallo Giuseppe, Rubini Giuseppe, Lattanzio Vincenzo, Berardi Tommaso
Department of General and Special Surgery, University of Bari, Italy.
Breast. 2007 Jun;16(3):316-22. doi: 10.1016/j.breast.2006.12.012. Epub 2007 Feb 9.
We performed subdermal injection of (99m)Tc-labelled albumin combined with subareolar (SA) injection of blue dye to axillary lymphatic mapping and sentinel lymph node biopsy (SLNB) in patients with multifocal and multicentric breast cancer to evaluate the feasibility and accuracy of this technique. A retrospective analysis of our experience on 235 SLNB showed that 30(12.7%) had multiple cancer (MC) on final pathologic examination and was considered in relation to the aim of the study. Mean age was 57.19 years (range 24-90). Mean number of SLNs identified was 1.93 (range 1-5). Mean number of axillary LNs examined was 18.10 (range 12-27). Overall successful identification was 100% with a false negative (FN) rate of 6.25%. Overall accuracy of lymphatic mapping and sensitivity was 96.6% and 93.7%, respectively. SLNB using the SA injection technique may be an alternative to complete axillary dissection in patients with multiple breast cancers and a clinically negative axilla.
我们对多灶性和多中心性乳腺癌患者进行皮下注射（99m）Tc标记的白蛋白并在乳晕下（SA）注射蓝色染料以进行腋窝淋巴绘图和前哨淋巴结活检（SLNB），以评估该技术的可行性和准确性。对我们235例SLNB经验的回顾性分析显示，30例（12.7%）在最终病理检查中有多原发癌（MC），并根据研究目的进行了分析。平均年龄为57.19岁（范围24 - 90岁）。识别出的前哨淋巴结平均数量为1.93个（范围1 - 5个）。检查的腋窝淋巴结平均数量为18.10个（范围12 - 27个）。总体成功识别率为100%，假阴性（FN）率为6.25%。淋巴绘图的总体准确率和敏感性分别为96.6%和93.7%。对于多灶性乳腺癌且腋窝临床阴性的患者，采用SA注射技术进行SLNB可能是完全腋窝清扫术的一种替代方法。
