肠道淋巴细胞迁移：我们已“行至半途”。

Gut lymphocyte migration: we are halfway 'home'.

作者信息

McGhee Jerry R, Kunisawa Jun, Kiyono Hiroshi

机构信息

Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA.

出版信息

Trends Immunol. 2007 Apr;28(4):150-3. doi: 10.1016/j.it.2007.02.001. Epub 2007 Feb 9.

DOI:10.1016/j.it.2007.02.001

PMID:17293162

Abstract

The gastrointestinal immune system consists of immune cells in organized gut-associated lymphoreticular tissues (GALT) and diffuse lamina propria, which give rise to mucosal secretory IgA antibody responses. A recent study showed that the retinoic acid produced by GALT dendritic cells (DCs) imprints B cells for gut homing. Surprisingly, GALT DCs, together with interleukin-5 (IL-5) and IL-6, also provided a milieu for both B cell switching to IgA and IgA synthesis.

摘要

胃肠道免疫系统由有组织的肠道相关淋巴网状组织（GALT）和弥漫性固有层中的免疫细胞组成，这些细胞可引发粘膜分泌性IgA抗体反应。最近的一项研究表明，GALT树突状细胞（DC）产生的视黄酸可使B细胞获得肠道归巢特性。令人惊讶的是，GALT DC与白细胞介素-5（IL-5）和IL-6一起，还为B细胞向IgA转换和IgA合成提供了环境。