[林奇综合征与妇科癌症：随访建议]

[Lynch syndrome and gynaecologic's cancer: follow-up recommendations].

作者信息

Magri K, Millon G

机构信息

Service de Chirurgie Générale, Viscérale et Vasculaire, CHG de Lons-le-Saunier, 55, rue du Docteur-Jean-Michel, BP 364, 39016 Lons-le-Saunier cedex, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2007 Feb;36(1):68-71. doi: 10.1016/j.jgyn.2006.09.005. Epub 2007 Jan 9.

DOI:10.1016/j.jgyn.2006.09.005

PMID:17293255

Abstract

The Lynch syndrome or HNPCC, is due to a mutation of the genes pertaining to the system MMR. This frequency varies from 1/1000 to 1/400. It's responsible for 6% of endométrial cancers, 2% of ovarian cancers and 1 to 3% of colorectal cancers. A good knowledge of this syndrome is necessary for doing the diagnosis and adjustment of gynaecological and colorectal follow-up. The authors report four cases in Lynch syndrome family.

摘要

林奇综合征或遗传性非息肉病性结直肠癌（HNPCC），是由于错配修复（MMR）系统相关基因的突变所致。其发病率从1/1000至1/400不等。它导致6%的子宫内膜癌、2%的卵巢癌以及1%至3%的结直肠癌。充分了解该综合征对于进行妇科和结直肠随访的诊断及调整至关重要。作者报告了林奇综合征家族中的4个病例。