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An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2602-7. doi: 10.1073/pnas.0611213104. Epub 2007 Feb 9.
2
Natural Compounds and Their Analogues as Potent Antidotes against the Most Poisonous Bacterial Toxin.
Appl Environ Microbiol. 2018 Nov 30;84(24). doi: 10.1128/AEM.01280-18. Print 2018 Dec 15.
3
Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.
Acc Chem Res. 2019 Aug 20;52(8):2322-2331. doi: 10.1021/acs.accounts.9b00261. Epub 2019 Jul 19.
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Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.
Bioorg Med Chem. 2011 Dec 15;19(24):7338-48. doi: 10.1016/j.bmc.2011.10.062. Epub 2011 Oct 26.
8
Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography.
Bioorg Med Chem. 2015 Nov 15;23(22):7264-73. doi: 10.1016/j.bmc.2015.10.024. Epub 2015 Oct 17.

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A novel RRGW derived peptide is a promising inhibitor of BoNT/A.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2203878. doi: 10.1080/14756366.2023.2203878.
2
Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine.
Mol Med. 2022 Jun 3;28(1):61. doi: 10.1186/s10020-022-00487-4.
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A Rabbit Model for the Evaluation of Drugs for Treating the Chronic Phase of Botulism.
Toxins (Basel). 2021 Sep 24;13(10):679. doi: 10.3390/toxins13100679.
5
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach.
RSC Med Chem. 2021 May 19;12(6):960-969. doi: 10.1039/d1md00089f. eCollection 2021 Jun 23.
6
Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries.
Molecules. 2021 May 27;26(11):3213. doi: 10.3390/molecules26113213.
7
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.
J Med Chem. 2020 Oct 8;63(19):11100-11120. doi: 10.1021/acs.jmedchem.0c01006. Epub 2020 Sep 18.
8
Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.
Acc Chem Res. 2019 Aug 20;52(8):2322-2331. doi: 10.1021/acs.accounts.9b00261. Epub 2019 Jul 19.
9
Protein-Catalyzed Capture Agents.
Chem Rev. 2019 Sep 11;119(17):9950-9970. doi: 10.1021/acs.chemrev.8b00660. Epub 2019 Mar 6.
10
Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence.
ACS Chem Biol. 2019 Jan 18;14(1):76-87. doi: 10.1021/acschembio.8b00937. Epub 2019 Jan 8.

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3
Botulinum toxin: clinical use.
Parkinsonism Relat Disord. 2006 Sep;12(6):331-55. doi: 10.1016/j.parkreldis.2006.06.002. Epub 2006 Jul 25.
4
Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model.
Chem Commun (Camb). 2006 Aug 7(29):3063-5. doi: 10.1039/b603099h. Epub 2006 May 3.
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Human botulism immune globulin for the treatment of infant botulism.
N Engl J Med. 2006 Feb 2;354(5):462-71. doi: 10.1056/NEJMoa051926.
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A credit-card library approach for disrupting protein-protein interactions.
Bioorg Med Chem. 2006 Apr 15;14(8):2660-73. doi: 10.1016/j.bmc.2005.11.052. Epub 2005 Dec 27.
10
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A.
Bioorg Med Chem. 2006 Jan 15;14(2):395-408. doi: 10.1016/j.bmc.2005.08.018. Epub 2005 Oct 3.

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