Abel M S, McCandless D W
Department of Cell Biology and Anatomy, University of Health Sciences, Illinois 60064.
J Neurochem. 1992 Feb;58(2):740-4. doi: 10.1111/j.1471-4159.1992.tb09780.x.
Bilateral ischemia has been shown to alter the net brain levels of energy metabolites such as ATP, phosphocreatine, glucose, and glycogen. The amino acid neurotransmitter gamma-aminobutyric acid (GABA) exerts a tonic inhibitory influence on neural activity. The present studies were designed to evaluate the influence of elevated GABA levels on the metabolic sequelae of ischemia. The GABA transaminase inhibitor gamma-vinyl-GABA (GVG; vigabatrin) was administered to Mongolian gerbils before the production of a bilateral ischemic incident. GABA levels were elevated in all regions assayed. Levels of energy metabolites were also increased, an indication of reduced energy utilization. In control animals, in the absence of GVG, 1 min of bilateral ischemia produced decreases in the levels of all metabolites. In animals pretreated with GVG, the effects of 1 min of bilateral ischemia were attenuated. These data suggest that the level of ongoing activity may affect the response to an ischemic insult. Furthermore, GVG may have a clinical indication in reducing the effect of minor ischemic incidents.
双侧缺血已被证明会改变大脑中能量代谢物的净水平，如三磷酸腺苷（ATP）、磷酸肌酸、葡萄糖和糖原。氨基酸神经递质γ-氨基丁酸（GABA）对神经活动具有强直性抑制作用。本研究旨在评估GABA水平升高对缺血代谢后遗症的影响。在双侧缺血事件发生前，给蒙古沙鼠施用GABA转氨酶抑制剂γ-乙烯基-GABA（GVG；氨己烯酸）。所有检测区域的GABA水平均升高。能量代谢物水平也有所增加，这表明能量利用减少。在对照动物中，在没有GVG的情况下，1分钟的双侧缺血会导致所有代谢物水平下降。在用GVG预处理的动物中，1分钟双侧缺血的影响减弱。这些数据表明，持续活动水平可能会影响对缺血性损伤的反应。此外，GVG在减轻轻微缺血事件的影响方面可能具有临床应用价值。
