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[短生育间隔对妊娠结局的影响]

[Influence of short interpregnancy interval on pregnancy outcomes].

作者信息

Zilberman Beniamin

机构信息

Women's Health Center, Kupat Holim Meuthedet, Beit May Medical Center, Haifa.

出版信息

Harefuah. 2007 Jan;146(1):42-7, 78.

Abstract

Optimal interpregnancy interval (IPI) is an important issue affecting pregnancy results, fetal and maternal morbidity/mortality, and has economic, social and demographic significance. The definition of IPI has not yet been standardized, thereby affecting results and conclusions. It was found that pregnancies conceived 18 to 23 months after previous birth had the lowest risks of fetal complications--low birth weight, preterm birth, and small size for gestational age. Women with shorter IPI have higher risk of maternal mortality, hypertensive disorders of pregnancy, bleeding and anemia. Studies conducted in developing countries suggest longer IPI-3 to 5 years as the optimal IPI. The relation between short interpregnancy intervals and adverse perinatal outcomes has been attributed to maternal nutritional depletion, the competition theory and behavioral risk factors. It was proposed that there is a J-shaped association between IPI and adverse pregnancy outcomes. This is not the effect of other common reproductive risk factors. There is a need to inform women regarding the association between adverse pregnancy outcomes and interpregnancy intervals, as well as the benefits of optimizing that interval. Public health programs could identify women with other risk factors (for example substance abuse, such as tobacco or alcohol, or a young/advanced maternal age) for interventions to improve perinatal outcomes. There is also a need for more studies to define the optimal IPI under local conditions.

摘要

最佳妊娠间隔(IPI)是一个影响妊娠结局、胎儿及孕产妇发病率/死亡率的重要问题,具有经济、社会和人口统计学意义。IPI的定义尚未标准化,从而影响了研究结果和结论。研究发现,在上次分娩后18至23个月受孕的胎儿出现并发症(低出生体重、早产和小于胎龄儿)的风险最低。IPI较短的女性孕产妇死亡、妊娠高血压疾病、出血和贫血的风险较高。在发展中国家进行的研究表明,较长的IPI(3至5年)为最佳妊娠间隔。妊娠间隔短与不良围产期结局之间的关系归因于孕产妇营养消耗、竞争理论和行为风险因素。有人提出,IPI与不良妊娠结局之间呈J形关联。这并非其他常见生殖风险因素的影响。有必要告知女性不良妊娠结局与妊娠间隔之间的关联,以及优化该间隔的益处。公共卫生项目可以识别出有其他风险因素(例如药物滥用,如吸烟或饮酒,或孕产妇年龄过小/过大)的女性,以便进行干预以改善围产期结局。还需要更多研究来确定当地条件下的最佳IPI。

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