Santiago Rolanía Olga, Guàrdia Olmos Joan, Arbizu Urdiain Txomin
Unidad de Esclerosis Múltiple (L'Hosptalet de Llobregat, Barcelona), Spain.
Psicothema. 2006 Feb;18(1):84-7.
Previous papers have mainly demonstrated the presence of cognitive impairment in patients with multiple sclerosis (MS), these changes have been traditionally associated with the later stages of the disease. In the current study, a comprehensive neuropsychological battery was administered to 216 relapsing-remitting MS patients with mild clinical disability (EDSS<or=3.5) and to 35 healty controls. The results show the presence of significant memory impairment: learning rate of list of words; reproduction visual memory; and long term verbal memory of texts, and information processing speed. We also observed greeter incidence of depressive symptoms in patients. And a little relation of the cognitive deficits with the clinical variables in these phase of the disease.
以往的论文主要证明了多发性硬化症（MS）患者存在认知障碍，这些变化传统上与疾病的后期阶段相关。在当前的研究中，对216名临床残疾程度较轻（扩展残疾状态量表评分≤3.5）的复发缓解型MS患者和35名健康对照者进行了全面的神经心理测试。结果显示存在显著的记忆障碍：单词列表的学习率、视觉记忆再现、文本的长期言语记忆以及信息处理速度。我们还观察到患者中抑郁症状的发生率更高。并且在疾病的这个阶段，认知缺陷与临床变量之间存在微弱的关联。
