Navarro José Francisco, Burón Estrella, Martín-López Mercedes
Facultad de Psicología, Universidad de Málaga, Spain.
Psicothema. 2006 Feb;18(1):100-4.
Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects of SB-205384 (0.5-4 mg/kg, i.p.), an alpha3 subunit positive modulator of GABA-A receptor, on anxiety tested in the elevated plus-maze in male mice, using classical and ethological parameters. Mice treated with SB-205384 showed an increase in the frequency of entries and the time spent in open arms, as well as a reduction in the time spent in closed arms, as compared with the control group. A notable increase of "head-dipping" unprotected and a reduction of "stretched-attend posture" protected was also evident. These findings indicate that SB-205384 exhibits an anxiolytic-like profile in the elevated plus-maze test, suggesting that GABA-A receptors which contain the alpha3 subunit might be involved in regulation of anxiety.
最近的研究表明，含α2的GABA - A受体在调节焦虑方面起主要作用。然而，含α3亚基的GABA - A受体对焦虑的潜在影响尚鲜为人知。本研究的目的是使用经典和行为学参数，检测GABA - A受体的α3亚基阳性调节剂SB - 205384（0.5 - 4mg/kg，腹腔注射）对雄性小鼠高架十字迷宫中焦虑测试的影响。与对照组相比，用SB - 205384处理的小鼠进入开放臂的频率和在开放臂中停留的时间增加，而在封闭臂中停留的时间减少。“头部探入”未受保护状态的显著增加和“伸展关注姿势”受保护状态的减少也很明显。这些发现表明，SB - 205384在高架十字迷宫试验中表现出抗焦虑样特征，提示含α3亚基的GABA - A受体可能参与焦虑调节。
