Bazrgar Masood, Karimi Mehran, Peiravian Farah, Fathzadeh Mohsen
Haematologica. 2007 Feb;92(2):256-7. doi: 10.3324/haematol.10708.
Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
左心室（LV）衰竭是地中海贫血患者的主要死因。地中海贫血患者的铁过载会导致氧自由基的形成。在各种载脂蛋白E（apoE）等位基因中，与apoE2和apoE3相比，apoE4在氧化应激条件下效率最低。我们的研究结果表明，apoE4是地中海贫血患者左心室功能障碍的遗传危险因素。
