Auwerda Johannes J A, Sonneveld Pieter, de Maat Monica P M, Leebeek Frank W G
Haematologica. 2007 Feb;92(2):279-80. doi: 10.3324/haematol.10454.
Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor (vWF) and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.
对未经治疗的多发性骨髓瘤患者的血栓前凝血异常进行了分析。观察到因子VIII、血管性血友病因子（vWF）增加以及蛋白S减少，且这些变化与疾病分期密切相关。有和没有随后发生静脉血栓栓塞的患者之间，基线凝血参数没有差异。
