Miller Kenneth A, Martin Stephen F
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Org Lett. 2007 Mar 15;9(6):1113-6. doi: 10.1021/ol0700761. Epub 2007 Feb 14.
A novel enantioselective total synthesis of (-)-alstonerine has been completed that requires only 15 steps from L-tryptophan. The synthesis features the first application of a Pauson-Khand reaction to synthesize an azabridged bicyclic skeleton. [reaction: see text]
已完成对(-)-阿斯托宁的新型对映选择性全合成,该合成从L-色氨酸开始仅需15步。该合成的特点是首次应用Pauson-Khand反应来合成氮杂桥联双环骨架。[反应:见正文]