Department of Chemistry, The University of Texas at Austin , Austin, Texas 78712, United States.
J Org Chem. 2017 Oct 20;82(20):10757-10794. doi: 10.1021/acs.joc.7b01368. Epub 2017 Sep 15.
Diverse structural types of natural products and their mimics have served as targets of opportunity in our laboratory to inspire the discovery and development of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures. Furthermore, our efforts toward identifying novel compounds having useful biological properties led to the creation of new targets, many of which posed synthetic challenges that required the invention of new methodology. In this Perspective, selected examples of how we have exploited a diverse range of natural products and their mimics to create, explore, and solve a variety of problems in chemistry and biology will be discussed. The journey was not without its twists and turns, but the unexpected often led to new revelations and insights. Indeed, in our recent excursion into applications of synthetic organic chemistry to neuroscience, avoiding the more-traveled paths was richly rewarding.
天然产物及其类似物的不同结构类型一直是我们实验室的研究目标，这些目标激发了我们发现和开发新方法和策略，以构建多功能和多环分子结构。此外，我们努力寻找具有有用生物特性的新型化合物，这导致了新目标的出现，其中许多目标都具有合成挑战，需要发明新的方法。在本观点中，将讨论我们如何利用各种天然产物及其类似物来创建、探索和解决化学和生物学中各种问题的一些示例。这一过程并非一帆风顺，但意想不到的情况往往会带来新的发现和见解。事实上，在我们最近将合成有机化学应用于神经科学的探索中，不走寻常路得到了丰厚的回报。
