豚鼠过敏反应期间前列腺素释放与肺组织环磷酸腺苷水平之间的关系。

The relationship between prostaglandin release and lung c-AMP levels during anaphylaxis in the guinea-pig.

作者信息

Barrett-Bee K J, Green L R

出版信息

Prostaglandins. 1975 Oct;10(4):589-98. doi: 10.1016/s0090-6980(75)80005-0.

Abstract

A four-fold transient rise in c-AMP levels was seen when sensitized guinea-pig lungs were challenged with antigen in vitro. This rise in c-AMP also occurred in vivo and was shown to be due to release of Prostaglandin E2. This conclusion is supported by the finding that inhibitors of prostaglandin synthesis (Indomethacin and Poly phloretin phosphate) prevent the rise in c-AMP while neither ICI 74, 917, an inhibitor of histamine release, nor antihistamines had any effect on the c-AMP levels.

摘要

当致敏的豚鼠肺在体外受到抗原攻击时，可观察到环磷酸腺苷（c-AMP）水平出现四倍的短暂升高。这种c-AMP的升高在体内也会发生，并且已证明是由于前列腺素E2的释放所致。这一结论得到以下发现的支持：前列腺素合成抑制剂（吲哚美辛和聚磷酸根皮苷）可阻止c-AMP的升高，而组胺释放抑制剂ICI 74,917和抗组胺药对c-AMP水平均无任何影响。