前列腺素E2和F2α的肺代谢产物对豚鼠呼吸道的影响。

Effects of pulmonary metabolites of prostaglandins E2 and F2alpha on guinea-pig respiratory tract.

作者信息

Lo P Y

出版信息

J Pharm Pharmacol. 1977 Dec;29(12):752-5. doi: 10.1111/j.2042-7158.1977.tb11455.x.

DOI:10.1111/j.2042-7158.1977.tb11455.x

Abstract

The effects of three pulmonary metabolites of prostaglandins E2 and F2alpha on the guinea-pig tracheal muscle in vitro and on lung resistance in vivo were investigated. Prostaglandin F2alpha, 13,14-dihydro PGF2alpha and 13,14-dihydro 15-oxo PGF2alpha produced contractions on the tracheal muscle in vitro. 15-oxo PGF2alpha relaxed some tracheal preparations but stimulated others, the stimulant action having a threshold dose range some 10-25 times lower than the relaxant doses. Prostaglandin F2alpha and 13,14-dihydro PGF2alpha increased lung resistance in anaesthetized guinea-pigs. Prostaglandin E2 and its three pulmonary metabolites produced relaxation of guinea pig trachea in vitro and decreased lung resistance in vivo. All three metabolites were less active than PGE2 in both the systems. The in vitro effects of PGF2alpha and its metabolites were selectively blocked by polyphloretin phosphate.

摘要

研究了前列腺素E2和F2α的三种肺代谢产物对豚鼠气管平滑肌的体外作用以及对肺阻力的体内作用。前列腺素F2α、13,14-二氢PGF2α和13,14-二氢15-氧代PGF2α在体外可使气管平滑肌收缩。15-氧代PGF2α可使一些气管标本松弛，但也可刺激另一些标本，其刺激作用的阈剂量范围比松弛剂量低约10-25倍。前列腺素F2α和13,14-二氢PGF2α可增加麻醉豚鼠的肺阻力。前列腺素E2及其三种肺代谢产物在体外可使豚鼠气管松弛，在体内可降低肺阻力。在这两个系统中，所有三种代谢产物的活性均低于PGE2。PGF2α及其代谢产物的体外作用可被聚磷酸根皮素选择性阻断。