Pekkarinen P T, von Hertzen L, Laatikainen T, Mäkelä M J, Jousilahti P, Kosunen T U, Pantelejev V, Vartiainen E, Haahtela T
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Allergy. 2007 Mar;62(3):281-7. doi: 10.1111/j.1398-9995.2006.01249.x.
A substantial variation in the association of asthma, rhinitis and eczema with elevated serum allergen-specific immunoglobulin E (sIgE) levels between different populations has been reported. Here, we wanted to clarify whether these proportions are different in Finnish and Russian Karelia, and compared the ability of questionnaires, skin prick tests (SPT) and sIgE measurements to detect atopic conditions in these adjacent areas with different living conditions.
Randomly selected schoolchildren, aged 6-16 years, and their mothers from Finland (n = 344 children, 344 mothers) and Russia (427 and 284 respectively) participated. SPTs and sIgE measurements to common inhalant and food allergens were performed. The occurrence of asthma, rhinitis, eczema and related symptoms was assessed with an International Study of Asthma and Allergies in Childhood-based questionnaire. Correlation between SPT and sIgE was estimated using the Spearman correlation coefficient.
The rate of positive sIgE results was significantly higher in Finland among both mothers and children. Seventy-seven per cent of Finnish children and 43% of Russian children with asthma were sIgE positive. The respective figures for hay fever were 94% and 67%, and for eczema 68% and 41%. This discrepancy was similar but of lower magnitude among mothers. The overall occurrence of asthma, rhinitis and eczema was very low in Russian Karelia. The correlation between SPT and sIgE results was generally good.
Asthma, rhinitis and eczema in Russian Karelia are not only rare but also, to a large extent, have no sIgE component. Therefore, the ability of questionnaires to detect sIgE-mediated atopic conditions in this area of Russia is poor.
据报道，不同人群中哮喘、鼻炎和湿疹与血清过敏原特异性免疫球蛋白E（sIgE）水平升高之间的关联存在很大差异。在此，我们想明确芬兰和俄罗斯卡累利阿地区这些比例是否不同，并比较问卷调查、皮肤点刺试验（SPT）和sIgE检测在这些生活条件不同的相邻地区检测特应性疾病的能力。
随机选取6至16岁的学童及其母亲参与研究，其中芬兰有344名儿童和344名母亲，俄罗斯分别有427名儿童和284名母亲。对常见吸入性和食物过敏原进行了SPT和sIgE检测。使用基于儿童哮喘和过敏国际研究的问卷评估哮喘、鼻炎、湿疹及相关症状的发生情况。采用Spearman相关系数估计SPT与sIgE之间的相关性。
芬兰母亲和儿童中sIgE阳性结果的比例显著更高。芬兰77%的哮喘儿童和俄罗斯43%的哮喘儿童sIgE呈阳性。花粉症的相应数字分别为94%和67%，湿疹为68%和41%。母亲中的差异相似但程度较低。俄罗斯卡累利阿地区哮喘、鼻炎和湿疹的总体发生率非常低。SPT与sIgE结果之间的相关性总体良好。
俄罗斯卡累利阿地区的哮喘、鼻炎和湿疹不仅罕见，而且在很大程度上不存在sIgE成分。因此，问卷调查在俄罗斯该地区检测sIgE介导的特应性疾病的能力较差。
