Skripchenko A, Balch A, Mackin A, Wagner S J
Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA.
Vox Sang. 2007 Feb;92(2):157-9. doi: 10.1111/j.1423-0410.2006.00864.x.
Recently, we have shown that thiopyrylium has robust inactivation capabilities against a broad spectrum of pathogens in the human red blood cell (RBC) suspensions while retaining key RBC in vitro properties. The 24-h recovery and survival of canine red cells were measured upon autologus reinfusion of control and phototreated units. The 24-h recovery of control and phototreated RBCs was 75.7 +/- 6.4% and 87.5 +/- 8.5%, respectively. The time for 50% survival of labelled control RBCs was similar to that of phototreated group (206 +/- 58 h vs. 255 +/- 63 h, respectively). Results suggest that thiopyrylium phototreatment does not negatively affect canine RBC in vivo recovery.
最近，我们已经表明，硫代吡喃鎓对人红细胞（RBC）悬液中的广谱病原体具有强大的灭活能力，同时保留了关键的RBC体外特性。在对对照和光处理单位进行自体回输后，测量了犬红细胞的24小时恢复率和存活率。对照和光处理的RBC的24小时恢复率分别为75.7±6.4%和87.5±8.5%。标记的对照RBC的50%存活时间与光处理组相似（分别为206±58小时和255±63小时）。结果表明，硫代吡喃鎓光处理不会对犬RBC的体内恢复产生负面影响。
