泰国北部注射吸毒和非注射吸毒的HIV阴性吸毒者的死亡率预测因素。

Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand.

作者信息

Quan Vu Minh, Vongchak Tasanai, Jittiwutikarn Jaroon, Kawichai Surinda, Srirak Namtip, Wiboonnatakul Kanokporn, Razak Myat Htoo, Suriyanon Vinai, Celentano David D

机构信息

Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.

出版信息

Addiction. 2007 Mar;102(3):441-6. doi: 10.1111/j.1360-0443.2006.01709.x.

DOI:10.1111/j.1360-0443.2006.01709.x

PMID:17298652

Abstract

AIMS

To estimate mortality rates among HIV-negative injecting drug users (IDUs) and non-injecting drug users (non-IDUs), and to assess predictors for mortality among the IDUs.

DESIGN

Prospective cohort study in northern Thailand with 2-year follow-up.

SETTING

IDUs and non-IDUs who were admitted for detoxification treatment for opiate or amphetamine dependence in a regional drug treatment center were screened. After discharge, HIV-negative individuals were followed-up in the community.

PARTICIPANTS

A total of 821 HIV-negative drug users [346 IDUs (42%) and 475 non-IDUs, median age = 32; 51% were ethnic minorities].

MEASUREMENTS

All-cause mortality.

FINDINGS

There were 33 deaths over 1360 person-years of follow-up. The all-cause mortality rate was 39 per 1000 person-years among IDUs [standardized mortality ratio (SMR) = 13.9], and was 14 per 1000 person-years among non-IDUs (SMR = 4.4). Among male IDUs, the hazards for all-cause deaths were ethnic minority status [adjusted hazard ratio (HR) = 2.9, 95% CI = 1.2-7.2], incident HIV infection (HR = 2.8, 95% CI = 1.1-7.7) and longer duration of drug injection (HR = 1.07, 95% CI = 1.01-1.14).

CONCLUSIONS

The mortality among IDUs is high. Being from an ethnic minority, recent HIV acquisition, and a greater number of years of drug injection are predictors of mortality among the IDUs in this region.

摘要

目的

估计艾滋病毒阴性注射吸毒者（IDU）和非注射吸毒者（非IDU）的死亡率，并评估IDU死亡率的预测因素。

设计

在泰国北部进行的前瞻性队列研究，随访2年。

地点

对在区域戒毒治疗中心接受阿片类或苯丙胺类药物依赖解毒治疗的IDU和非IDU进行筛查。出院后，对艾滋病毒阴性个体在社区进行随访。

参与者

共有821名艾滋病毒阴性吸毒者[346名IDU（42%）和475名非IDU，中位年龄=32岁；51%为少数民族]。

测量指标

全因死亡率。

研究结果

在1360人年的随访期间有33例死亡。IDU的全因死亡率为每1000人年39例[标准化死亡率（SMR）=13.9]，非IDU为每1000人年14例（SMR=4.4）。在男性IDU中，全因死亡的危险因素包括少数民族身份[调整后的风险比（HR）=2.9，95%置信区间（CI）=1.2-7.2]、新发艾滋病毒感染（HR=2.8，95%CI=1.1-7.7）和更长的注射吸毒持续时间（HR=1.07，95%CI=1.01-1.14）。