del Mar Matarín María, Pueyo Roser, Poca María Antonia, Falcón Carles, Mataró María, Bargalló Núria, Sahuquillo Juan, Junqué Carme
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain.
J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):760-3. doi: 10.1136/jnnp.2006.088450. Epub 2007 Feb 13.
Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.
We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.
1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.
After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
MRS could be a marker of neuronal dysfunction in NPH.
成人正常压力脑积水(NPH)是少数几种潜在可治疗的痴呆病因之一。一些归因于脑积水的形态和功能异常在治疗后有所改善。
我们专注于分析NPH治疗后使用质子磁共振波谱(1H-MRS)检测脑代谢物的变化及其与临床和认知的相关性。
对12例特发性NPH成人患者在分流术前和术后6个月进行1H-MRS、神经心理学和临床状态检查。我们获取了N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌醇(MI)和肌酸(Cr)的值。
术后,NAA/Cr显著升高。此外,NAA/Cr值与认知功能恶化有关。
MRS可能是NPH中神经元功能障碍的一个标志物。