Baranov A A, Mar'iandyshev A O, Nizovtseva N I, Oparina E N, Presnova S E, Gvozdovskaia L A, Markelov Iu M, Trekin I A, Tungusova O S, Mannsoker T
Probl Tuberk Bolezn Legk. 2006(12):9-12.
The paper describes the results of radiometric BACTEC assay of drug susceptibility of Mycobacterium tuberculosis strains, isolated from 81 new cases of tuberculosis, to first- and second-line antituberculosis drugs in four administrative areas of the North-Western Federal District of the Russian Federation. The results of determination of drug susceptibility to the antituberculosis drugs by the absolute concentration method and the BACTEC method are also compared. Primary drug resistance has been revealed in 58.0%; multidrug resistance in 34.6%. Comparison of the results of determination of drug susceptibility by the methods revealed no significant discrepancy between both methods; however, the procedure for drug susceptibility to some drugs requires improvement.
该论文描述了对从俄罗斯联邦西北联邦区四个行政区的81例新肺结核病例中分离出的结核分枝杆菌菌株，进行放射性BACTEC药物敏感性检测，以检测其对一线和二线抗结核药物的敏感性结果。还比较了用绝对浓度法和BACTEC法测定抗结核药物敏感性的结果。发现原发性耐药率为58.0%；多重耐药率为34.6%。两种方法的药物敏感性测定结果比较显示，两种方法之间没有显著差异；然而，某些药物的药物敏感性检测程序需要改进。
