Shapiro Robert E, Tepper Stewart J
Department of Neurology, College of Medicine, University of Vermont, Burlington, VT, USA.
Headache. 2007 Feb;47(2):266-9. doi: 10.1111/j.1526-4610.2006.00691.x.
The serotonin syndrome is an acute adverse reaction to medications that enhance serotonergic activity. The severity of cases ranges from mild to fatal. Recently, the U.S. Food and Drug Administration issued an alert that the risk of developing serotonin syndrome may be increased by the concomitant administration of triptan medications with certain other medications. However, a review of published data does not allow an accurate assessment of such risks related to triptans. We conclude that it is currently unclear whether administration of triptans with other serotonergic medications increases the risk of serotonin syndrome.
血清素综合征是一种对增强血清素能活性的药物产生的急性不良反应。病例严重程度从轻度到致命不等。最近，美国食品药品监督管理局发布警报称，曲坦类药物与某些其他药物同时使用可能会增加发生血清素综合征的风险。然而，对已发表数据的审查无法准确评估与曲坦类药物相关的此类风险。我们得出结论，目前尚不清楚曲坦类药物与其他血清素能药物同时使用是否会增加血清素综合征的风险。
