Leffler Daniel A, Dennis Melinda, Edwards George Jessica B, Kelly Ciaran P
The Celiac Center, Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana, Boston, MA 02215, USA.
Eur J Gastroenterol Hepatol. 2007 Mar;19(3):251-5. doi: 10.1097/MEG.0b013e328012db37.
Celiac disease is an inflammatory disorder in which certain peptides from wheat and related grains trigger and maintain an immune reaction in the small intestine. Anorexia nervosa and bulimia nervosa are eating disorders that are morbid and, at times, life-threatening forms of psychopathology. Despite a large body of evidence describing the detrimental effects of eating disorders on the gastrointestinal system, information on the role of the gastrointestinal system in causing or mimicking eating disorders is scarce. To date, eating disorders, as a comorbid condition affecting individuals with celiac disease, has received surprisingly little attention with only a single report found in peer-reviewed literature. In this report, we describe a series of 10 individuals with both celiac disease and eating disorders. These cases demonstrate the complex ways in which celiac disease and eating disorders interact with important clinical implications for the diagnosis and treatment of both illnesses. Our findings suggest that clinicians treating patients with eating disorders or celiac disease should be aware of both conditions to provide optimum care.
乳糜泻是一种炎症性疾病，其中来自小麦及相关谷物的某些肽会引发并维持小肠中的免疫反应。神经性厌食症和神经性贪食症是饮食失调症，是病态的，有时甚至是危及生命的精神病理学形式。尽管有大量证据描述了饮食失调对胃肠系统的有害影响，但关于胃肠系统在导致或模拟饮食失调方面的作用的信息却很少。迄今为止，饮食失调作为一种影响乳糜泻患者的共病状况，令人惊讶地受到很少关注，在同行评审文献中仅发现一份报告。在本报告中，我们描述了10例同时患有乳糜泻和饮食失调的患者。这些病例展示了乳糜泻和饮食失调相互作用的复杂方式，对这两种疾病的诊断和治疗具有重要的临床意义。我们的研究结果表明，治疗饮食失调或乳糜泻患者的临床医生应该了解这两种情况，以便提供最佳护理。
