Saji Hideo
Graduate School of Pharmaceutical Sciences, Kyoto University.
Nihon Rinsho. 2007 Feb;65(2):363-9.
The nuclear medical imaging technologies, PET and SPECT, is sensitive in vivo imaging in biomedicine and have the power to obtain the information on the in vivo dynamic behaviors of drugs. There are some approaches in this field. First approach uses the drug labeled isotopically with an appropriate radionuclide and can obtain information on the tissue distribution and targeted point of drugs. Second approach, drug delivery imaging, is one that a radiolabel is incorporated into the dosage form with some methods and can be used toward the evaluation of the efficacy of a new formulation and route of administration of drug. Third approach is to assess the in vivo interaction between a targeted molecule and a drug, such as receptor binding, transporting ability and enzyme activity, using the radiolabeled ligand, based on the competition of a drug with the radioligand. Thus, molecular imaging used nuclear medical imaging technique can directly visualize the spatiotemporal distribution and interaction processes of drugs in human at the molecular level.
核医学成像技术，即正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT），在生物医学中对体内成像很敏感，并且有能力获取有关药物体内动态行为的信息。该领域有一些方法。第一种方法是使用用适当放射性核素进行同位素标记的药物，并且可以获得有关药物的组织分布和靶向点的信息。第二种方法，即药物递送成像，是一种通过某些方法将放射性标记掺入剂型中的方法，可用于评估新剂型的疗效和药物给药途径。第三种方法是基于药物与放射性配体的竞争，使用放射性标记的配体来评估靶向分子与药物之间的体内相互作用，例如受体结合、转运能力和酶活性。因此，使用核医学成像技术的分子成像可以在分子水平上直接可视化药物在人体内的时空分布和相互作用过程。
