Berenson G S, Turner M, O'Meallie L P, Puyau F A, Pargaonkar P S, Srinivasan S, Hall R J
South Med J. 1975 Dec;68(12):1513-9. doi: 10.1097/00007611-197512000-00014.
Extensive serum lipid analyses, with specific emphasis on the concentration of serum beta and pre-beta-lipoproteins, were made on 93 patients who had a clinical diagnosis of angina pectoris and were undergoing coronary angiographic studies. Those individuals with abnormal angiographic evidence of obstructive coronary artery disease, including a group with a prior myocardial infarction, have almost uniformly elevated serum beta-lipoprotein levels when related to an arbitrary division based on the mean values for a "normal" adult population at a similar age level. Compared to serum cholesterol and serum triglycerides, the serum lipoprotein concentrations, specifically beta-lipoproteins, appear to be a more useful parameter for predicting the existence of coronary artery disease. Further studies relating clinical risk factors to coronary artery disease might be better approached by using angiography of coronary vessels rather than myocardial infarction or sudden death from coronary artery disease as an endpoint of morbid data.
对93例临床诊断为心绞痛且正在接受冠状动脉造影研究的患者进行了广泛的血脂分析，特别着重于血清β脂蛋白和前β脂蛋白的浓度。那些冠状动脉造影显示有阻塞性冠状动脉疾病异常证据的个体，包括有过心肌梗死的一组，与基于相似年龄水平的“正常”成年人群平均值的任意划分相比，其血清β脂蛋白水平几乎都升高。与血清胆固醇和血清甘油三酯相比，血清脂蛋白浓度，特别是β脂蛋白，似乎是预测冠状动脉疾病存在的更有用参数。进一步将临床危险因素与冠状动脉疾病相关联的研究，使用冠状动脉血管造影而非心肌梗死或冠状动脉疾病猝死作为病态数据的终点，可能会有更好的研究方法。
