Caramello Valeria, Dovio Andrea, Caraci Pasquale, Berruti Alfredo, Angeli Alberto
Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospitals, Orbassano, Turin, Italy.
Int J Urol. 2007 Feb;14(2):150-2. doi: 10.1111/j.1442-2042.2006.01644.x.
Thrombotic thrombocytopenic purpura (TTP) is a generalized disorder of the microcirculation characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenic purpura and systemic microvascular thrombi. TTP has been previously described in two patients with prostate cancer (PC). We report a third case of TTP in a 61-year-old man with hormone-refractory bone metastatic PC. The syndrome presented with confusion, anuric acute renal failure, thrombocytopenia and MHA. A satisfactory recovery was achieved after plasma exchange (PE). TTP should be included in the coagulation disorders occurring in PC patients. Early treatment with plasma exchange is recommended in these particular cases.
血栓性血小板减少性紫癜（TTP）是一种微循环的全身性疾病，其特征为微血管病性溶血性贫血（MHA）、血小板减少性紫癜和全身微血管血栓形成。此前已有两名前列腺癌（PC）患者被描述患有TTP。我们报告了第三例TTP病例，患者为一名61岁的激素难治性骨转移性PC男性。该综合征表现为意识模糊、无尿性急性肾衰竭、血小板减少和MHA。血浆置换（PE）后实现了满意的康复。TTP应纳入PC患者发生的凝血障碍中。在这些特殊病例中，建议早期进行血浆置换治疗。
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