Nakayama Daisuke, Masuzaki Hideaki, Miura Kiyonori, Hiraki Koichi, Yoshimura Shu-Ichiro, Ishimaru Tadayuki
Department of Obstetrics and Gynecology, Nagasaki University Faculty of Medicine, Nagasaki 852-8501, Japan.
Contraception. 2007 Mar;75(3):238-40. doi: 10.1016/j.contraception.2006.11.001. Epub 2007 Jan 16.
The study was conducted to determine whether placenta previa increases bleeding during gemeprost-induced termination of second-trimester pregnancy.
We carried out a retrospective study of 158 second-trimester terminations between 12 and 21 weeks' gestation. We compared the intraoperative blood loss among three groups: women without placenta previa undergoing gemeprost termination, women with placenta previa undergoing gemeprost termination and women with placenta previa undergoing dilatation and evacuation (D&E).
Eleven of 158 women (7.0%) had placenta previa; four underwent D&E and seven had gemeprost termination. There was no statistical difference in mean intraoperative blood loss among the three groups, although one of the seven women with placenta previa who underwent gemeprost termination developed serious bleeding requiring blood transfusion.
The use of gemeprost for second-trimester pregnancy termination in women with placenta previa seems to be relatively safe and does not increase intraoperative blood loss in the majority of cases.
