Kwon-Chung K J, Edman J C, Wickes B L
Clinical Mycology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Infect Immun. 1992 Feb;60(2):602-5. doi: 10.1128/iai.60.2.602-605.1992.
A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (alpha mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five alpha type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, alpha type was clearly more virulent than a type. In addition, death tended to occur earlier among the alpha-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.
构建了一对同基因的新型隐球菌变种新型隐球菌菌株，即B - 4476（a交配型）和B - 4500（α交配型），据推测它们仅在交配型上存在差异。对这一对菌株及其后代（五个α型和五个a型）进行了小鼠毒力测试。在亲代菌株及其后代中，α型明显比a型更具毒力。此外，死于α菌株感染的小鼠往往比死于a菌株感染的小鼠死亡时间更早。这些数据有力地表明了在这种人类真菌病原体中毒力与交配型之间存在遗传关联。
