Rivas Ruiz R, Guzmán Cabañas J Maria, Párraga Quiles Maria J, Ruiz González Maria D, Huertas Muñoz Maria D, Alvarez Marcos R, Zapatero Martínez M
Unidad de Cuidados Intensivos Neonatales, Hospital de Pediatría del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F.
An Pediatr (Barc). 2007 Feb;66(2):140-5. doi: 10.1157/13098931.
To assess the utility of the CRIB score as a predictor of hospital death and intraventricular hemorrhage (IVH) in very low birth weight (VLBW) and extremely low birth weight (ELBW) neonates.
A prospective cohort of VLBW neonates admitted to the neonatal intensive care unit from January 2002 to December 2004 was studied. The data was assessed following the protocol of the SEN 1500 multicenter study. This protocol included assessment of the CRIB score in the first 12 hours of life. Data for the entire group, as well as for two subgroups divided according to birth weight (BW) - VLBW neonates (between 1000 and 1500 g) and ELBW neonates (below 1,000 g) - were evaluated. The area under the receiver operating characteristic curve (Az) was calculated to assess the utility of CRIB score, BW and gestational age (GA). Two multivariate models were used.
The cohort consisted of 163 patients. The mean (+/-SD) birthweight was 1.114 (+/-270) g and gestational age (+/-SD) was 29 (+/-3) weeks. The Az for hospital death was 0.757 for the CRIB, 0.758 for BW and 0.703 for GA. The Az for IVH was 0.66 for the CRIB, 0.62 for BW and 0.64 for GA. In the multivariate models for hospital death and IVH, the CRIB was the best predictor. The Az of the CRIB for hospital death was 0.77 for VLBW neonates (p < 0.001) and 0.63 for ELBW neonates (p = 0.82).
The predictive utility of the CRIB for hospital death and IVH is similar to that of BW. In the stratification by groups of weight, we found that the CRIB was the best predictor of hospital death in the group weighing > 1,000 g but was no better than chance in the group weighing < 1,000 g.
评估CRIB评分对极低出生体重（VLBW）和超低出生体重（ELBW）新生儿医院死亡及脑室内出血（IVH）的预测效用。
对2002年1月至2004年12月入住新生儿重症监护病房的VLBW新生儿进行前瞻性队列研究。按照SEN 1500多中心研究方案评估数据。该方案包括在出生后12小时内评估CRIB评分。对整个组以及根据出生体重（BW）分为的两个亚组——VLBW新生儿（1000至1500克之间）和ELBW新生儿（低于1000克）——的数据进行评估。计算受试者工作特征曲线下面积（Az）以评估CRIB评分、BW和胎龄（GA）的效用。使用了两个多变量模型。
该队列包括163例患者。平均（±标准差）出生体重为1.114（±270）克，胎龄（±标准差）为29（±3）周。CRIB评分预测医院死亡的Az为0.757，BW为0.758，GA为0.703。CRIB评分预测IVH的Az为0.66，BW为0.62，GA为0.64。在医院死亡和IVH的多变量模型中，CRIB是最佳预测指标。CRIB评分预测VLBW新生儿医院死亡的Az为0.77（p<0.001），预测ELBW新生儿医院死亡的Az为0.63（p = 0.82）。
CRIB评分对医院死亡和IVH的预测效用与BW相似。在按体重分组的分层中，我们发现CRIB评分是体重>1000克组医院死亡的最佳预测指标，但在体重<1000克组中并不比随机预测更好。
