Okiyoneda Tsukasa, Lukacs Gergely L
Hospital for Sick Children Research Institutes, Cell Biology, 555 University Av., Toronto, Ontario, Canada M5G 1X8.
Biochim Biophys Acta. 2007 Apr;1773(4):476-9. doi: 10.1016/j.bbamcr.2007.01.004. Epub 2007 Jan 19.
Ganeshan et al. (Biochem Biophys. Acta 1173 (2007) 192-200) recent study documents the effect of N-WASP inhibition and actin cytoskeleton disruption on the constitutive internalization and recycling of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. The results implicate the cytoskeleton network as a potential modulator of immobilized CFTR pool size at the plasma membrane and the recycling efficiency of endocytosed channel back to the cell surface.
加内山等人（《生物化学与生物物理学学报》1173卷（2007年）第192 - 200页）最近的研究记录了N - WASP抑制和肌动蛋白细胞骨架破坏对囊性纤维化跨膜传导调节因子（CFTR）通道组成型内化和再循环的影响。结果表明细胞骨架网络可能是质膜上固定的CFTR池大小以及内吞通道回到细胞表面的再循环效率的潜在调节因子。
