Caldarella A, Crocetti E, Comin C E, Janni A, Pegna A Lopes, Paci E
Clinical Epidemiology, Center for Study and Cancer Prevention, Via di San Salvi 12, 50135 Florence, Italy.
Eur J Surg Oncol. 2007 Aug;33(6):763-8. doi: 10.1016/j.ejso.2007.01.001. Epub 2007 Feb 15.
A retrospective study including all patients with non-small cell lung cancer carcinoma in a population-based registry was performed to characterize gender differences in lung cancer and to analyze the factors influencing prognosis in women.
We retrieved through the Tuscan Cancer Registry (RTT) archive 2,523 lung tumor cases diagnosed during the period 1996-1998 in the provinces of Florence and Prato, central Italy. We compared the prognosis within 464 non-small lung cancer women and 1,798 men in a population-based case series. The influence of the following variables on postoperative survival were analyzed: age, cell type, pathologic T and N status, site of tumor and type of surgical resection.
The age at diagnosis was similar in women and in men. Women were significantly more likely to have adenocarcinoma but less likely to have squamous cell carcinoma compared with men. Fewer pneumonectomies were performed in women than in men. Nevertheless, prognosis was similar in both sexes and type of surgical resection was significant prognostic factor.
Lung cancer was more frequent in men than in women, but overall survival is similar. Differences in lung cancer histology and rate of pneumonectomies were found between men and women.
开展一项回顾性研究，纳入基于人群登记系统中的所有非小细胞肺癌患者，以描述肺癌的性别差异，并分析影响女性预后的因素。
我们通过托斯卡纳癌症登记处（RTT）档案，检索了1996年至1998年期间在意大利中部佛罗伦萨省和普拉托省诊断出的2523例肺部肿瘤病例。在一个基于人群的病例系列中，我们比较了464例非小细胞肺癌女性和1798例男性的预后。分析了以下变量对术后生存的影响：年龄、细胞类型、病理T和N状态、肿瘤部位以及手术切除类型。
女性和男性的诊断年龄相似。与男性相比，女性患腺癌的可能性显著更高，但患鳞状细胞癌的可能性更低。女性接受全肺切除术的比例低于男性。然而，两性的预后相似，手术切除类型是一个重要的预后因素。
男性肺癌比女性更常见，但总体生存率相似。发现男性和女性在肺癌组织学和全肺切除率方面存在差异。
