涉及三环氧化鎓叶立德中间体的多组分反应：非对映选择性合成单和双烷氧基八氢-1,4-苯并二恶英-6(5H)-酮骨架

Multicomponent reactions involving tricyclooxonium ylide intermediate: diastereoselective synthesis of mono- and bisalkoxyoctahydro-1,4-benzodioxocin-6(5H)-one frameworks.

作者信息

Muthusamy Sengodagounder, Krishnamurthi Janagiraman, Suresh Eringathodi

机构信息

School of Chemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu, 620 024, India.

出版信息

Chem Commun (Camb). 2007 Feb 28(8):861-3. doi: 10.1039/b613008a. Epub 2006 Nov 24.

DOI:10.1039/b613008a

PMID:17308656

Abstract

A highly diastereoselective tandem ring-enlargement and aldol condensation process involving multicomponent reactions of ethereal tricyclooxonium ylide intermediate with alcohols, mono- or dialdehydes in the presence of titanium(iv) isopropoxide is described to furnish alkoxyoctahydro-1,4-benzodioxocin-6(5H)-one ring systems.

摘要

描述了一种高度非对映选择性的串联扩环和羟醛缩合过程，该过程涉及在异丙醇钛存在下，醚类三环氧化鎓叶立德中间体与醇、单醛或二醛的多组分反应，以提供烷氧基八氢-1,4-苯并二恶英-6(5H)-酮环系。