2-脱氧-2-[F-18]氟-D-葡萄糖正电子发射断层扫描成像在土拨鼠肝细胞癌模型中的定量评估及其与组织学的相关性
Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation.
作者信息
Salem Nicolas, MacLennan Gregory T, Kuang Yu, Anderson Paul W, Schomisch Steve J, Tochkov Ilia A, Tennant Bud C, Lee Zhenghong
机构信息
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Mol Imaging Biol. 2007 May-Jun;9(3):135-43. doi: 10.1007/s11307-007-0092-5.
PURPOSE
The Eastern woodchuck (Marmota monax) is considered as a naturally occurring animal model of hepatocellular carcinoma (HCC). The performance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study.
PROCEDURES
Dynamic FDG-PET scans were performed on five woodchucks with HCC and one healthy woodchuck before removal and processing of the liver tissues for histology. The parameters of a two-tissue compartment model with dual input were estimated using weighted least squares (WLS).
RESULTS
Ten HCCs were confirmed histologically. Six HCCs had a tumor-to-liver standardized uptake value (SUV) ratio < or =1.15, a k (4) / k (3) ratio similar to that in hepatic tissues and were well-differentiated. Four HCCs had a tumor-to-liver SUV ratio >1.15, a lower k (4) / k (3) ratio than the hepatic tissues and were moderately differentiated.
CONCLUSIONS
Increased FDG uptake was observed in HCCs that were the least differentiated and correlated with a lower k (4) / k (3) ratio.
目的
东部土拨鼠（Marmota monax）被视为肝细胞癌（HCC）的天然动物模型。本研究调查了2-脱氧-2-[F-18]氟-D-葡萄糖（FDG）在土拨鼠身上使用正电子发射断层扫描（PET）对HCC进行成像的性能。
程序
在对五只患有HCC的土拨鼠和一只健康土拨鼠进行肝脏组织切除和组织学处理之前，进行了动态FDG-PET扫描。使用加权最小二乘法（WLS）估计具有双输入的双组织隔室模型的参数。
结果
组织学确诊10例HCC。6例HCC的肿瘤与肝脏标准化摄取值（SUV）比值≤1.15，k（4）/k（3）比值与肝组织相似，分化良好。4例HCC的肿瘤与肝脏SUV比值>1.15，k（4）/k（3）比值低于肝组织，分化中等。
结论
在分化程度最低的HCC中观察到FDG摄取增加，且与较低的k（4）/k（3）比值相关。
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