Wingerchuk D M, Pittock S J, Lucchinetti C F, Lennon V A, Weinshenker B G
Department of Neurology, Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.
Neurology. 2007 Feb 20;68(8):603-5. doi: 10.1212/01.wnl.0000254502.87233.9a.
We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.
我们将96例视神经脊髓炎（NMO）患者的临床病程与多发性硬化症（MS）的自然史数据进行了比较。根据随访数据的分布（中位数为6.1年），我们估计21例NMO患者会转变为继发进展型病程，但我们仅观察到2例转变（p = 0.00002；相对风险 = 0.08）。MS和NMO不同的自然史表明，中枢神经系统脱髓鞘疾病的复发与临床进展之间存在分离。
