Moore L A, Tidyman W E, Arrizubieta M J, Bandman E
Department of Food Science and Technology, University of California, Davis 95616.
J Mol Biol. 1992 Jan 5;223(1):383-7. doi: 10.1016/0022-2836(92)90741-2.
Comparisons of the nucleotide sequences of the light meromyosin (LMM) region of developmentally regulated fast chicken myosin heavy chain (MHC) isoforms indicates that chicken MHC isoforms are more similar to each other than to MHC isoforms in other species. The sequence data provide evidence that gene conversion events have occurred recently among the isoforms. An embryonic (Cemb1) isoform and neonatal isoform have the most extensive regions of sequence identity. Similar gene conversion events are present in the rat alpha- and beta-cardiac MHCs, but were not obvious in the LMM of developmentally regulated fast human MHC isoforms. The data suggest that gene conversion events can play a significant role in the evolution of the MHC multigene families and that concerted evolution of the chicken multigene family occurred after the divergence of mammals and avians.
对发育调控的快速型鸡肌球蛋白重链（MHC）亚型的轻酶解肌球蛋白（LMM）区域核苷酸序列进行比较表明，鸡的MHC亚型彼此之间的相似性高于与其他物种的MHC亚型。序列数据证明，这些亚型之间最近发生了基因转换事件。一种胚胎型（Cemb1）亚型和新生型亚型具有最广泛的序列同一性区域。类似的基因转换事件也存在于大鼠的α-和β-心脏MHC中，但在发育调控的快速型人类MHC亚型的LMM中并不明显。这些数据表明，基因转换事件可能在MHC多基因家族的进化中发挥重要作用，并且鸡多基因家族的协同进化发生在哺乳动物和鸟类分化之后。
