Bandman E, Moore L A, Arrizubieta M J, Tidyman W E, Herman L, Wick M
Department of Food Science and Technology, University of California at Davis 95616.
Soc Gen Physiol Ser. 1994;49:129-39.
This manuscript describes the chicken sarcomeric myosin heavy chain (MyHC) multigene family and how it differs from the sarcomeric MyHC multigene families of other vertebrates. Data is discussed that suggests the chicken fast MyHC multigene family has undergone recent expansion subsequent to the divergence of avians and mammals, and has been subjected to multiple gene conversion-like events. Similar to human and rodent MyHC multigene families, the chicken multigene family contains sarcomeric MyHC genes that are differentially regulated in developing embryonic, fetal, and neonatal muscles. However, unlike mammalian genes, chicken fast MyHC genes expressed in developing muscles are also expressed in mature muscle fibers as well. The potential significance of conserved and divergent sequences with the MyHC rod domain of five fast chicken isoforms that have been cloned and sequenced is also discussed.
本手稿描述了鸡的肌节肌球蛋白重链（MyHC）多基因家族，以及它与其他脊椎动物的肌节MyHC多基因家族有何不同。文中讨论的数据表明，鸡的快速MyHC多基因家族在鸟类和哺乳动物分化之后经历了近期的扩张，并且经历了多次类似基因转换的事件。与人类和啮齿动物的MyHC多基因家族相似，鸡的多基因家族包含在发育中的胚胎、胎儿和新生儿肌肉中受到差异调节的肌节MyHC基因。然而，与哺乳动物基因不同的是，在发育中的肌肉中表达的鸡快速MyHC基因在成熟肌纤维中也有表达。文中还讨论了已克隆和测序的五种快速鸡亚型的MyHC杆状结构域中保守和 divergent 序列的潜在意义。
