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人类免疫缺陷病毒1型跨膜包膜蛋白中保守的半胱氨酸残基对于前体包膜的切割至关重要。

Conserved cysteine residues in the human immunodeficiency virus type 1 transmembrane envelope protein are essential for precursor envelope cleavage.

作者信息

Dedera D, Gu R L, Ratner L

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

J Virol. 1992 Feb;66(2):1207-9. doi: 10.1128/JVI.66.2.1207-1209.1992.

DOI:10.1128/JVI.66.2.1207-1209.1992
PMID:1731099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC240828/
Abstract

The transmembrane (TM) protein of human immunodeficiency virus type 1 has been demonstrated to be involved in viral infectivity and syncytium formation. Two highly conserved cysteine residues in the extracellular region of the TM protein are shown to be essential for processing the 160-kDa envelope precursor into the active 120- and 41-kDa mature forms.

摘要

人类免疫缺陷病毒1型的跨膜（TM）蛋白已被证明与病毒感染性和多核体形成有关。TM蛋白胞外区域的两个高度保守的半胱氨酸残基对于将160 kDa包膜前体加工成活性120 kDa和41 kDa成熟形式至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e268/240828/5e96fb556509/jvirol00035-0610-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e268/240828/5e96fb556509/jvirol00035-0610-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e268/240828/5e96fb556509/jvirol00035-0610-a.jpg

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Conserved cysteine residues in the human immunodeficiency virus type 1 transmembrane envelope protein are essential for precursor envelope cleavage.人类免疫缺陷病毒1型跨膜包膜蛋白中保守的半胱氨酸残基对于前体包膜的切割至关重要。
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2
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