一只圈养极地狼（Canis lupus arctos）中表达Tp53的扁桃体鳞状细胞癌。

Tp53 expressing squamous cell carcinoma of the tonsil in a captive polar wolf (Canis lupus arctos).

作者信息

Teifke Jens P, Löhr Christiane V, Langner Christoph

机构信息

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems, Germany.

出版信息

J Zoo Wildl Med. 2005 Sep;36(3):538-42. doi: 10.1638/04-019.1.

DOI:10.1638/04-019.1

PMID:17312781

Abstract

The gross and histopathologic findings for a primary tonsillar squamous cell carcinoma in a captive 11-yr-old male polar wolf (Canis lupus arctos) are described. The carcinoma had metastasized to regional lymph nodes of the pharynx, the precardial mediastinum, and the lungs. Tumor suppressor protein TP53 was detected by immunohistochemistry in the nuclei of poorly differentiated, cytokeratin-positive cells of the primary neoplasm and the metastases. Canine oral papillomavirus DNA was not detectable by polymerase chain reaction (PCR).

摘要

描述了一只圈养的11岁雄性极地狼（Canis lupus arctos）原发性扁桃体鳞状细胞癌的大体和组织病理学发现。该癌已转移至咽部区域淋巴结、心前纵隔和肺部。通过免疫组织化学在原发性肿瘤和转移灶的低分化、细胞角蛋白阳性细胞的细胞核中检测到肿瘤抑制蛋白TP53。通过聚合酶链反应（PCR）未检测到犬口腔乳头瘤病毒DNA。