Xi Yin-xue, Song Xin, Chen Hui-xin, Peng Ting-sheng, Chen Min-hu
Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Yi Xue Za Zhi. 2006 Dec 26;86(48):3405-8.
To investigate the expression of microvessel density (MVD) in multistep tissue of gastric carcinoma and CD34 in the multistep tissue of gastric carcinogens.
277 specimens of gastric diseases, 56 specimens of chronic gastritis, 50 specimens of chronic atrophic gastritis, 59 specimens of intestinal metaplasia, 61 specimens of dysplasia, 57 specimens of gastric carcinoma with lymph node metastases, and 55 specimens of gastric carcinoma without lymph node metastases, obtained from pathological department, Sun Yat-sen university, underwent pathological examination and immunohistochemistry to detect the expression of CD34 antigen that is expressed only in the endothelial cells in tumor.
The mean MVD was 13 +/- 10 in the specimens of chronic gastritis, 11 +/- 7 in the chronic atrophic gastritis group, 13 +/- 9 in the intestinal metaplasia group, 17 +/- 10 in the dysplasia group, 27 +/- 11 in the gastric carcinoma without lymph node metastases group, and 28 +/- 10 in the gastric carcinoma with lymph node metastases group. There were not significant differences in MVD among the chronic gastritis group, chronic atrophic gastritis group, and intestinal metaplasia group (all P > 0.05), there was a significant difference in MVD between the chronic gastritis group and dysplasia group (P < 0.05). In the specimens of gastric carcinoma, there were no significant difference in MVD between those with and without lymph node metastases (P > 0.05), and between those of high and low differentiation degrees (both P < 0.05).
The increase of expression of CD34 in the multistage tissues of gastric carcinoma is associated with the genesis of gastric cancer, and not be related to the gastric carcinoma metastases.
研究胃癌多步骤组织中微血管密度（MVD）及胃癌前病变多步骤组织中CD34的表达情况。
从中山大学病理科获取277例胃疾病标本，其中慢性胃炎56例、慢性萎缩性胃炎50例、肠化生59例、异型增生61例、有淋巴结转移的胃癌57例、无淋巴结转移的胃癌55例，进行病理检查及免疫组化，检测仅在肿瘤内皮细胞表达的CD34抗原的表达情况。
慢性胃炎标本中MVD均值为13±10，慢性萎缩性胃炎组为11±7，肠化生组为13±9，异型增生组为17±10，无淋巴结转移的胃癌组为27±11，有淋巴结转移的胃癌组为28±10。慢性胃炎组、慢性萎缩性胃炎组和肠化生组之间MVD差异无统计学意义（均P>0.05），慢性胃炎组与异型增生组之间MVD有显著差异（P<0.05）。在胃癌标本中，有淋巴结转移与无淋巴结转移者之间MVD差异无统计学意义（P>0.05），高分化与低分化者之间MVD差异均有统计学意义（均P<0.05）。
胃癌多阶段组织中CD34表达增加与胃癌发生有关，而与胃癌转移无关。
