韩国女性中ERCC1基因C19007T多态性及其与上皮性卵巢癌和子宫内膜癌风险的相关性。一项病例对照研究。
The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women. A case control study.
作者信息
Jo Hoenil, Kang Sokbom, Kim Sung Il, Kim Jae Weon, Park Noh Hyun, Song Yong Sang, Park Sang-Yoon, Kang Soon Beom, Lee Hyo Pyo
机构信息
Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea.
出版信息
Gynecol Obstet Invest. 2007;64(2):84-8. doi: 10.1159/000100008. Epub 2007 Feb 20.
BACKGROUND
Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis.
METHODS
We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects.
RESULTS
We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively).
CONCLUSION
Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women.
背景
切除修复交叉互补基因1（ERCC1）是一种主要的DNA修复蛋白。最近的研究探讨了ERCC1基因多态性与致癌作用之间的关联。
方法
我们调查了94例上皮性卵巢癌患者、102例子宫内膜癌患者以及329例对照者中ERCC1基因第19007位核苷酸（C→T，Asn118Asn）的多态性。
结果
我们没有观察到C19007T ERCC1基因多态性与上皮性卵巢癌或子宫内膜癌风险之间存在关联的证据，其调整后的优势比均为0.91（p值分别为0.711、0.691）。
结论
我们的研究结果表明，C19007T ERCC1基因多态性不太可能在韩国女性的上皮性卵巢癌或子宫内膜癌中发挥重要作用。
Zotero 插件