浅探皮肤发育
Scratching the surface of skin development.
作者信息
Fuchs Elaine
机构信息
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA.
出版信息
Nature. 2007 Feb 22;445(7130):834-42. doi: 10.1038/nature05659.
Abstract
The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.
摘要
表皮及其附属器由单层多能胚胎祖角质形成细胞发育而来。胚胎干细胞从其环境中接收信号，这些信号指导它们致力于特定的分化程序，并生成分层的表皮、毛囊或皮脂腺。最近令人兴奋的进展集中在成年皮肤上皮如何维持干细胞群体，以用于毛囊再生的自然周期以及在受伤时进行再上皮化。
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