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Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.Lgr6 标记毛囊中的干细胞，这些干细胞产生皮肤的所有细胞谱系。
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[Hair follicle as a novel source of stem cells].[毛囊作为干细胞的新来源]
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本文引用的文献

1
Mice cloned from skin cells.从皮肤细胞克隆的小鼠。
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2738-43. doi: 10.1073/pnas.0611358104. Epub 2007 Feb 13.
2
Catenins: keeping cells from getting their signals crossed.连环蛋白：防止细胞信号交叉。
Dev Cell. 2006 Nov;11(5):601-12. doi: 10.1016/j.devcel.2006.10.010.
3
Canonical notch signaling functions as a commitment switch in the epidermal lineage.经典的Notch信号传导在表皮谱系中作为一种决定开关发挥作用。
Genes Dev. 2006 Nov 1;20(21):3022-35. doi: 10.1101/gad.1477606.
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Tcf3 governs stem cell features and represses cell fate determination in skin.Tcf3调控皮肤中的干细胞特性并抑制细胞命运决定。
Cell. 2006 Oct 6;127(1):171-83. doi: 10.1016/j.cell.2006.07.036.
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Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.Blimp1定义了一个祖细胞群体，该群体控制着皮脂腺的细胞输入。
Cell. 2006 Aug 11;126(3):597-609. doi: 10.1016/j.cell.2006.06.048.
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Anatomic demarcation by positional variation in fibroblast gene expression programs.通过成纤维细胞基因表达程序中的位置变化进行解剖学划分。
PLoS Genet. 2006 Jul;2(7):e119. doi: 10.1371/journal.pgen.0020119.
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Epidermal stem cells of the skin.皮肤的表皮干细胞。
Annu Rev Cell Dev Biol. 2006;22:339-73. doi: 10.1146/annurev.cellbio.22.010305.104357.
8
Lhx2 maintains stem cell character in hair follicles.Lhx2维持毛囊中的干细胞特性。
Science. 2006 Jun 30;312(5782):1946-9. doi: 10.1126/science.1128004.
9
Generation of the primary hair follicle pattern.初级毛囊模式的形成。
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9075-80. doi: 10.1073/pnas.0600825103. Epub 2006 Jun 12.
10
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.转录抑制因子JHDM3A可使三甲基化组蛋白H3赖氨酸9和赖氨酸36发生去甲基化。
Nature. 2006 Jul 20;442(7100):312-6. doi: 10.1038/nature04853. Epub 2006 May 28.

浅探皮肤发育

Scratching the surface of skin development.

作者信息

Fuchs Elaine

机构信息

Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA.

出版信息

Nature. 2007 Feb 22;445(7130):834-42. doi: 10.1038/nature05659.

DOI:10.1038/nature05659
PMID:17314969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2405926/
Abstract

The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.

摘要

表皮及其附属器由单层多能胚胎祖角质形成细胞发育而来。胚胎干细胞从其环境中接收信号，这些信号指导它们致力于特定的分化程序，并生成分层的表皮、毛囊或皮脂腺。最近令人兴奋的进展集中在成年皮肤上皮如何维持干细胞群体，以用于毛囊再生的自然周期以及在受伤时进行再上皮化。