国际营养与衰老学会（IANA）专家组：体重减轻与阿尔茨海默病

IANA (International Academy on Nutrition and Aging) Expert Group: weight loss and Alzheimer's disease.

作者信息

Gillette Guyonnet S, Abellan Van Kan G, Alix E, Andrieu S, Belmin J, Berrut G, Bonnefoy M, Brocker P, Constans T, Ferry M, Ghisolfi-Marque A, Girard L, Gonthier R, Guerin O, Hervy M-P, Jouanny P, Laurain M-C, Lechowski L, Nourhashemi F, Raynaud-Simon A, Ritz P, Roche J, Rolland Y, Salva T, Vellas B

出版信息

J Nutr Health Aging. 2007 Jan-Feb;11(1):38-48.

PMID:17315079

Abstract

Weight loss, together with psychological and behavioural symptoms and problems of mobility, is one of the principal manifestations of Alzheimer's disease (AD). Weight loss may be associated with protein and energy malnutrition leading to severe complications (alteration of the immune system, muscular atrophy, loss of independence). Various explanations have been proposed such as atrophy of the mesial temporal cortex, biological disturbances, or feeding behaviours; however, none has been proven. Prevention of weight loss in AD is a major issue. It requires regular follow-up and must be an integral part of the care plan. The aim of this article is to review the present state of scientific knowledge on weight loss associated with AD. We will consider four points: the natural history of weight loss, its known etiological factors, its consequences and the various management options.

摘要

体重减轻，连同心理和行为症状以及行动能力问题，是阿尔茨海默病（AD）的主要表现之一。体重减轻可能与蛋白质和能量营养不良有关，进而导致严重并发症（免疫系统改变、肌肉萎缩、失去独立生活能力）。人们提出了各种解释，如内侧颞叶皮质萎缩、生物紊乱或进食行为等；然而，尚无一种解释得到证实。预防AD患者体重减轻是一个重大问题。这需要定期随访，并且必须成为护理计划的一个组成部分。本文的目的是综述与AD相关的体重减轻的科学知识现状。我们将考虑四个方面：体重减轻的自然病程、已知的病因、后果以及各种管理方案。